Results 121 to 130 of about 1,031,153 (395)

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Nature, 2021
Lei Han, Xiaoyu Wei, Chuanyu Liu, G. Volpe, Zhenkun Zhuang, Xuanxuan Zou, Zhifeng Wang, Taotao Pan, Yue Yuan, Xiao Zhang, Peng-sheng Fan, Pengcheng Guo, Yiwei Lai, Y. Lei, Xingyuan Liu, Feng Yu, Shuncheng Shangguan, Guang-Shun Lai, Q. Deng, Ya Liu, Liang Wu, Quan Shi, Hao Yu, Yunting Huang, Mengnan Cheng, Jiangshan Xu, Yang Liu, Mingyue Wang, Chunqing Wang, Yuanhang Zhang, Duo Xie, Yun-sheng Yang, Yeya Yu, Huiwen Zheng, Ya-rong Wei, F. Huang, Junjie Lei, Waidong Huang, Zhixin Zhu, Haorong Lu, Bo Wang, Xiaofeng Wei, Fengzhen Chen, Tao Yang, Wensi Du, Jingxin Chen, Shi-Bo Xu, J. An, C. Ward, Zongren Wang, Z. Pei, Chi-Wai Wong, Xiaolei Liu, Huafeng Zhang, Mingyuan Liu, Baoming Qin, A. Schambach, J. Isern, Liqiang Feng, Y. Liu, Xiangyu Guo, Zhen Liu, Qiang Sun, P. Maxwell, N. Barker, P. Muñoz-Cánoves, Ying Gu, J. Mulder, M. Uhlén, apple apple, Shiping Liu, Huanming Yang, Jian Wang, Yong Hou, Xun Xu, M. Esteban, Longqi Liu   +76 more
semanticscholar   +1 more source

Non-motor Characterization of the Basal Ganglia: Evidence From Human and Non-human Primate Electrophysiology

Frontiers in Neuroscience, 2018
Although the basal ganglia have been implicated in a growing list of human behaviors, they include some of the least understood nuclei in the brain. For several decades studies have employed numerous methodologies to uncover evidence pointing to the ...
R. Eisinger, Morgan E. Urdaneta, K. Foote, M. Okun, A. Gunduz   +4 more
semanticscholar   +1 more source

Network Desynchronization with Sine Waves: from Synchrony to Asynchrony by Periodic Stimulation

Advanced Science, EarlyView.
Exogenous alternating current fields are explored and interact with cerebral cortex slow waves in vitro and in silico. Varying frequency and amplitude of sine waves result in distinct network dynamics, from phase‐locking and entrainment to desynchronization. These responses occupy specific regions within the parameter space.
Joana Covelo, Martina Cortada, Gianni V. Vinci, Maurizio Mattia, Maria V. Sanchez‐Vives   +4 more
wiley   +1 more source

Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease

Translational Neurodegeneration
Amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD) are diverse in clinical presentation and are caused by complex and multiple factors, including genetic mutations and environmental factors.
Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li, Xiao-Jiang Li, Peng Yin   +5 more
doaj   +1 more source

VDAC in Retinal Health and Disease

Biomolecules
The retina, a tissue of the central nervous system, is vital for vision as its photoreceptors capture light and transform it into electrical signals, which are further processed before they are sent to the brain to be interpreted as images. The retina is
Ying Xu, Shanti R. Tummala, Xiongmin Chen, Noga Vardi   +3 more
doaj   +1 more source

Characterization of gut microbiome in a captive colony of marmosets

Berliner und Münchener Tierärztliche Wochenschrift, 2020
Although the microbiome signatures in primates are more similar to humans in comparison to microbiome of mice and rats, the study of microbiome in primate models and particularly in non-human primates such as the common marmoset (Callithrix jacchus) are ...
I J Knorr, L Benga, L Peitzmann, E Engelhardt, W Benten, C Gougoula, P Petzsch, K Köhrer, M Sager   +8 more
doaj   +1 more source

Can the Archaeology of Manual Specialization Tell Us Anything About Language Evolution? A Survey of the State of Play [PDF]

, 2009
In this review and position paper we explore the neural substrates for manual specialization and their possible connection with language and speech. We focus on two contrasting hypotheses of the origins of language and manual specialization: the language-
Steele, J, Uomini, N
core  

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Large-scale polymorphism discovery in macaque G-protein coupled receptors [PDF]

, 2013
Background: G-protein coupled receptors (GPCRs) play an inordinately large role in human health. Variation in the genes that encode these receptors is associated with numerous disorders across the entire spectrum of disease.
Goswami, Dharmendra B, Miller, Gregory M, Ogawa, Lisa M, Vallender, Eric J, Ward, Joshua M   +4 more
core   +2 more sources

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source