Results 41 to 50 of about 890,490 (213)
Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos
Scientific Reports, 2017 CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome.
Zhuchi Tu +12 more
semanticscholar +1 more source
Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina.
Human Gene Therapy, 2017 Within the next decade, we will see many gene therapy clinical trials for eye diseases, which may lead to treatments for thousands of visually impaired people around the world.
Pavitra S. Ramachandran +11 more
semanticscholar +1 more source
Current state of research on non‐human primate models of Alzheimer’s disease
Animal Models and Experimental Medicine, 2019 With the increasingly serious aging of the global population, dementia has already become a severe clinical challenge on a global scale. Dementia caused by Alzheimer's disease (AD) is the most common form of dementia observed in the elderly, but its ...
Hong-Wei Li, Ling Zhang, Chuan Qin
semanticscholar +1 more source
Xenotransplantation, 2015 Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4GalNT2 glycosyltransferase may also synthesize xenoantigens.
J. Estrada +9 more
semanticscholar +1 more source
HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice
Cell Death and DiseaseHuntington’s disease (HD) is a monogenic neurodegenerative disease, caused by the CAG trinucleotide repeat expansion in exon 1 of the Huntingtin (HTT) gene. The HTT gene encodes a large protein known to interact with many proteins.
Laiqiang Chen +13 more
doaj +1 more source
Laboratory Animals. Journal of the Laboratory Animal Science Association, 2019 The genetic and biological similarity between non-human primates and humans has ensured the continued use of primates in biomedical research where other species cannot be used.
Ivan Balansard +5 more
semanticscholar +1 more source
Beyond MRI: on the scientific value of combining non-human primate neuroimaging with metadata
NeuroImage, 2021 Sharing and pooling large amounts of non-human primate neuroimaging data offer new exciting opportunities to understand the primate brain. The potential of big data in non-human primate neuroimaging could however be tremendously enhanced by combining ...
Colline Poirier +8 more
doaj
Brain and Behavior, 2023 Objective Anxious behaviors often occur in individuals who have experienced early adversity. Anxious behaviors can bring many hazards, such as social withdrawal, eating disorders, negative self‐efficacy, self‐injurious thoughts and behaviors, anxiety ...
Xiao‐Li Feng +11 more
doaj +1 more source
American Journal of Primatology, 2018 Research with non‐human primates (NHP) has been essential and effective in increasing our ability to find cures for a large number of diseases that cause human suffering and death.
J. Park, Afonso C. Silva
semanticscholar +1 more source
Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV. [PDF]
PLoS ONE, 2016 Interferon-induced transmembrane (IFITM) proteins are potent antiviral factors shown to restrict the infection of many enveloped viruses, including HIV. Here we report cloning and characterization of a panel of nonhuman primate IFITMs.
Jordan Wilkins +4 more
doaj +1 more source