Results 221 to 230 of about 317,227 (291)

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

An aptamer-drug conjugate for promising cancer therapy with comprehensive evaluation from rodents to non-human primates. [PDF]

Signal Transduct Target Ther
Su M, Liu Y, Lin H, Wang X, Ying D, Zhang L, Yang C, Jiang M, Xu L, Wang X, Sun Y, Xu H, Zhang Z, Wang X, Fu T, Xie S, He J, Liu X, Tan W.   +18 more
europepmc   +1 more source

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Assessment of antigen-specific T cell recall responses in non-human primates using a composite AIM assay. [PDF]

Front Immunol
Schmidt JM, Prasad M, Degner K, Schiavo R, Repic A, Little L, Israel L, Chen F, Hansen R, Karle AC, Leenhouts K, Sørensen P, McIntosh B, Brees D, Carballido JM.   +14 more
europepmc   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Evaluation of [¹⁸F]MNI-1054, a novel PET ligand for lysine-specific histone demethylase 1A (LSD1), in non-human primates. [PDF]

EJNMMI Res
Petibon Y, Takano A, Schwarz AJ, Yardibi O, Sandiego C, Barret O, Constantinescu C, Tauscher J, McQuade P.   +8 more
europepmc   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Clinical Scale MSC-Derived Extracellular Vesicles Enhance Poststroke Neuroplasticity in Rodents and Non-Human Primates. [PDF]

J Extracell Vesicles
Kim EH, Son JP, Oh GS, Park S, Hong E, Lee KS, Chopp M, Bang OY.   +7 more
europepmc   +1 more source

Vicarious Touch: A Potential Substitute for Social Touch During Touch Deprivation

European Journal of Social Psychology, EarlyView.
ABSTRACT Restricted interpersonal touch experiences, for instance due to COVID‐19 social distancing measures, result in detrimental effects on anxiety, loneliness and psychological well‐being. Yet, interventions capable of mitigating the impact of social touch deprivation, as experienced during the COVID‐19 pandemic, remain insufficient. In this study,
Louise P. Kirsch, Mariana von Mohr, Athanasios Koukoutsakis, Aikaterini Fotopoulou   +3 more
wiley   +1 more source