Results 201 to 210 of about 317,061 (307)

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source

Glucocorticoids suppress early lung inflammation and impair control of SARS-CoV-2 in non-human primates. [PDF]

PLoS One
Nelson CE, Kauffman KD, Sakai S, Newbolt T, Buchanan J, Foreman TW, Walker AM, Gomez F, Fleegle JD, Tuberculosis Imaging Program, Herbert R, Hill T, Turan S, Mayer-Barber KD, Johnson RF, Via LE, Barber DL.   +16 more
europepmc   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Protocol for testing global neuronal workspace and integrated information theories of consciousness in non-human primates and mice. [PDF]

PLoS One
Gibbons M, McBride EG, Holenarasipura Venkatasubbaiah R, Khalili-Ardali M, Kuyat JR, Gale S, LaFehr V, Vogler NW, Kheirkhah Ravandi M, Tsai MJ, Bennett C, Sridhar A, Hardcastle B, Cabasco H, Koch C, Naccache L, Tononi G, Olsen S, Neimark Geffen M, Panagiotaropoulos TI, Saalmann YB.   +20 more
europepmc   +1 more source

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović, Kent W. Nilsson, Robert Fredriksson, Helgi B. Schiöth, Thiago C. Moulin   +4 more
wiley   +1 more source

Assessment of Chronic Multi-Electrode Spinal Cord Electrical Stimulation and Electromyography Platform in Non-Human Primates. [PDF]

Biomedicines
Militskova AD, Andrianov VV, Biktimirov AR, Gulaev EV, Alfimova TB, Shkap MO, Burachek LA, Panfilov RV, Bulgin DV, Zhirnov SV, Trashkov AP, Lavrov IA, Baklaushev VP.   +12 more
europepmc   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

A Survey of the Reproductive Lesions in Captive Female Non-Human Primates in Italy. [PDF]

Vet Sci
Galietta V, Cocumelli C, Parmigiani R, Bovi E, Palmerini T, Acri C, Di Cerbo P, Aloisi M, Cersini A, Eleni C.   +9 more
europepmc   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates. [PDF]

Proteomics
Tschirner SK, Schmidt A, Ito M, Hyakkoku K, Yoshimura A, Müller SA, Horiguchi N, Lichtenthaler SF.   +7 more
europepmc   +1 more source