Results 191 to 200 of about 165,398 (266)

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

A Survey of the Reproductive Lesions in Captive Female Non-Human Primates in Italy. [PDF]

Vet Sci
Galietta V, Cocumelli C, Parmigiani R, Bovi E, Palmerini T, Acri C, Di Cerbo P, Aloisi M, Cersini A, Eleni C.   +9 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Assessment of Chronic Multi-Electrode Spinal Cord Electrical Stimulation and Electromyography Platform in Non-Human Primates. [PDF]

Biomedicines
Militskova AD, Andrianov VV, Biktimirov AR, Gulaev EV, Alfimova TB, Shkap MO, Burachek LA, Panfilov RV, Bulgin DV, Zhirnov SV, Trashkov AP, Lavrov IA, Baklaushev VP.   +12 more
europepmc   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates. [PDF]

Proteomics
Tschirner SK, Schmidt A, Ito M, Hyakkoku K, Yoshimura A, Müller SA, Horiguchi N, Lichtenthaler SF.   +7 more
europepmc   +1 more source

Pioneering the canine model in microbiota–gut–brain research for social and affective disorders

iMetaOmics, EarlyView.
This commentary highlights the translational potential of canine models in investigating the microbiota–gut–brain (MGB) axis, focusing on their relevance to human social cognition and affective disorders, including major depressive disorder and autism spectrum disorder.
Yun Yu, Qiuhan Wen, Xiaoyang Wang, Mengyu Song, Tifei Yuan, Feilong Deng, Jianmin Chai, Ying Li, Ya‐Ping Zhang   +8 more
wiley   +1 more source

Phenotypic and Genotype Patterns of Antimicrobial Resistance in Non-Human Primates: An Overlooked "One Health" Concern. [PDF]

Antibiotics (Basel)
Wen J, Okyere SK, Shi Y, Qu Y, Chen C.
europepmc   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Relationship Between Periodontal Disease and Systemic Diseases in Non-Human Primates. [PDF]

Vet Sci
Miranda BP, da Silva AF, Ascenção JC, Dos Reis RB, Teixeira MVM, Miglionico MTS, Santos HLC.   +6 more
europepmc   +1 more source