Results 171 to 180 of about 317,061 (307)

Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source

Host-anellovirus interactions in an island ecosystem: non-human primates and rodents in Madagascar harbour diverse, rich anellovirus populations. [PDF]

Microb Genom
Paietta EN, Johnston RA, Randrianarisoa SF, DeSisto CMM, Kraberger S, Martin D, Razanamahenina TT, Ramboninarimalala A, Velontsara JB, Raherinirina TG, Rasendrinirina V, Raveloson L, Luo Y, Finley NL, Baitchman E, Yoder AD, Varsani A.   +16 more
europepmc   +1 more source

Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo, Nagamani Vunnam, Jonathan N. Sachs, Benjamin J. Hackel   +3 more
wiley   +1 more source

MHC matching improves engraftment of iPSC-derived neurons in non-human primates [PDF]

, 2017
et al,, Glasser, Matthew F
core   +2 more sources

Infection with Mycobacterium tuberculosis depletes host fatty acids in humans and non-human primates. [PDF]

EBioMedicine
Collins JM, Wassie L, Bobosha K, Gandhi NR, Liu KH, Day CL, Rengarajan J, Kempker RR, Lau MSY, Nellis M, Nizam A, Maner-Smith K, Ortlund EA, Sakai S, Kauffman KD, Magee MJ, Jones DP, Ernst JD, Barber DL, Blumberg HM, TBRU-ASTRa Study Group.   +20 more
europepmc   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Retrograde optogenetics reveals sensorimotor convergence within a corticotectal pathway of non-human primates. [PDF]

Curr Biol
Yu X, Gopal A, Inoue KI, Bohlen MO, Kuczewski GM, Sommer MA, Nienborg H, Takada M, Hikosaka O.   +8 more
europepmc   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Kinetics of rabies-neutralising antibodies in non-human primates after the injection of adjuvanted and inactivated rabies vaccine. [PDF]

Onderstepoort J Vet Res
Souissi Y, Handous M, Bayoudh M, Torjemane S, Khamassi Khbou M.   +4 more
europepmc   +1 more source

Placental crises: disruptive selection and maternal under‐investment as the foundations of mammalian placental evolution and dysfunction

Biological Reviews, EarlyView.
ABSTRACT Among the vertebrates, mammals are notable for the dominance of live birth and placental nutrition. The structural diversity of the mammalian placenta is remarkable, despite sharing a single common ancestor and conserved physiological functions.
Davis Laundon, Neil J. Gostling, Ian G. Reddin, Bram G. Sengers, Pascale Chavatte‐Palmer, Rohan M. Lewis   +5 more
wiley   +1 more source