Exploring the involvement of the alternative complement pathway in non-infectious uveitis pathogenesis [PDF]
Frontiers in Immunology, 2023 PurposeNon-infectious uveitis is a complex disease characterized by intraocular inflammation of the uveal area and the leading cause of vision impairment and blindness in young people globally.
Prerna Kulshrestha +7 more
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Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis [PDF]
Clinical & Translational Immunology, 2023 Characterised by intraocular inflammation, non‐infectious uveitis includes a large group of autoimmune and autoinflammatory diseases that either involve the eye alone or have both ocular and systemic manifestations.
Lisia Barros Ferreira +4 more
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Association between polycystic ovary syndrome and non-infectious uveitis [PDF]
Scientific Reports, 2023 Polycystic ovary syndrome (PCOS) is a common endocrine disease in young women. It has been reported that increased proinflammatory cytokines can induce systemic inflammation. However, the association between PCOS and uveitis remains elusive.
Chae Eun Lee +6 more
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Autoimmune and autoinflammatory mechanisms in uveitis [PDF]
Seminars in Immunopathology, 2014 The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve tissue and cellular function in the face of immune-mediated insult ...
H Nida Şen +2 more
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Pharmacotherapy for non-infectious uveitis: spotlight on phase III clinical trials of locally injected or implanted therapeutics and systemic immunomodulatory drugs [PDF]
Journal of Ophthalmic Inflammation and InfectionBackground Non-infectious uveitis is an uncommon eye condition, but an important cause of substantial vision impairment and blindness around the world.
Melissa K. Shields +6 more
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Outcome of adalimumab monotherapy in paediatric non-infectious uveitis [PDF]
Pediatric Rheumatology Online Journal, 2023 Background Adalimumab in combination with other disease-modifying antirheumatic drugs (DMARD) such as methotrexate has a proven efficacy in the management of paediatric non-infectious uveitis.
DA Al-Julandani +6 more
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Autoimmunity, Autoinflammation, and Infection in Uveitis [PDF]
American Journal of Ophthalmology, 2018 Funding/Support: No funding or grant support. Financial Disclosures: John V. Forrester has received an honorarium for lecturing from Janssen (London, UK). Lucia Kuffova has undertaken consultancy work for Abbvie (London, UK). Andrew D.
Lucia Kuffova, Andrew D Dick
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Topical Anti-Inflammatory Agents for Non-Infectious Uveitis: Current Treatment and Perspectives [PDF]
Journal of Inflammation Research, 2022 Balini Balasubramaniam,1 Yu Jeat Chong,2 Matthew Azzopardi,3 Abison Logeswaran,4 Alastair K Denniston1 1Ophthalmology Department, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK; 2Birmingham ...
Balasubramaniam B +4 more
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Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial [PDF]
Lancet, The, 2016 Background Non-infectious uveitis is a potentially sight-threatening ocular disorder caused by chronic inflammation and its complications. Therapeutic success is limited by systemic adverse effects associated with long-term corticosteroid and ...
Quan Dong Nguyen +2 more
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Prevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study [PDF]
BMC OphthalmologyBackground The prevalence of ocular sarcoidosis (OS) varies across Asia and the application of the most recent revised diagnostic criteria has not yet been fully adopted. Thus, the prevalence of OS within the Chinese population remains uncertain.
Daquan He +4 more
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