Results 61 to 70 of about 10,417,976 (225)

Involvement of B cells in non-infectious uveitis [PDF]

, 2016
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the ...
Strempel, Andrew, Appukuttan, Binoy, Smith, Justine R, Bharadwaj, A S   +3 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

GENDER BIAS IN UVEITIS: RESULTS FROM A STUDY AT ARMED FORCES INSTITUTE OF OPHTHALMOLOGY RAWALPINDI

Pakistan Armed Forces Medical Journal, 2020
Objective: Current study aimed at finding the differences in etiology of uveitis among male and female genders among patients presenting to the Uveitis Clinic of AFIO, Rawalpindi. Study Design: Cross sectional study.
Noman Nazir Ahmed, Quratulain Zamir, Umar Ijaz, Muhammad Shahid, Shahid Iqbal   +4 more
doaj   +2 more sources

Certolizumab pegol – Tumor necrosis factor inhibitor for refractory uveitis

American Journal of Ophthalmology Case Reports, 2020
Purpose: The purpose of our study is to report our experience with the use of certolizumab pegol in patients with refractory non-infectious uveitis. Observations: We present a case series of three patients with non-infectious uveitis, treated with twice ...
Yael Sharon, David S. Chu
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Searching for viral antibodies and genome in intraocular fluids of patients with Fuchs uveitis and non-infectious uveitis

, 2013
To characterise the polyspecific intraocular antibody synthesis in aqueous humor of patients with Fuchs uveitis and other types of non-infectious ...
R. Aldigeri, A. Invernizzi, Luca Cimino, Carlo Salvarani, Belloni, Lucia, Aldigeri, Raffaella, Parmeggiani, Maria, Cappuccini, Luca, FONTANA L, Luca Cappuccini, Invernizzi, Alessandro, Raffaella Aldigeri, Fontana, Luigi, M. Parmeggiani, Alessandro Invernizzi, L. Fontana, Cimino, Luca, Lucia Belloni, L. Belloni, C. Salvarani, Carlo Alberto Zotti, SALVARANI, CARLO, L. Cimino, Maria Parmeggiani, Zotti, Carlo Alberto, C. A. Zotti, L. Cappuccini   +26 more
core   +3 more sources

Incidence of COVID-19 Vaccination-Related Uveitis and Effects of Booster Dose in a Tertiary Uveitis Referral Center

Frontiers in Medicine, 2022
BackgroundWe report vaccine and booster-related uveitis in Singapore, a country with high vaccination and booster rates to highlight the differences and potential role of prophylactic treatment for sight-threatening infectious uveitis.MethodsClinical ...
Milton C. Chew, Shaan Wiryasaputra, Meihui Wu, Wei Boon Khor, Anita S. Y. Chan, Anita S. Y. Chan, Anita S. Y. Chan   +6 more
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Laboratory Investigations in Infectious Uveitis

, 2023
20.500.12530/87908Laboratory investigations can play a significant role in the diagnosis and decision-making of infectious uveitis. Though direct demonstration of the infective organism remains the gold standard of diagnosis, it is not always possible ...
Julio J González-López, Biswas, Jyotirmay, Parthopratim Dutta Majumder, Sharma, Megha, Mochizuki, Manabu, John Gonzales, Sharma, Kusum, Manabu Mochizuki, Jyotirmay Biswas, Megha Sharma, Gonzales, John, González-López, Julio J, Kusum Sharma, Dutta Majumder, Parthopratim   +13 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source