Results 101 to 110 of about 8,526,529 (317)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Improving Invasive Animal Institutions: A citizen-focused approach. A citizen-focused review of institutional arrangements for Invasive Animal management

, 2014
This report discusses rules and responsibilities, property rights, administration, funding and management and other 'institutional' issues that affect landholders, volunteers, businesses, community groups or other non-government organisations (NGO's ...
Martin, Paul, Marshall, Graham R, Le Gal, Elodie, Dickson, Katrina, Low Choy, Darryl   +4 more
core  

Non-invasive and invasive preimplantation genetic testing workflow.

, 2018
Non-invasive and invasive preimplantation genetic testing workflow.
Ran Antes (417275), Gelareh Motamedi (5204534), Svetlana Madjunkova (658226), Rina Abramov (5204528), Zenon Ibarrientos (5204531), Clifford Librach (3751186), Valeriy Kuznyetsov (4093663)   +6 more
core   +1 more source

Non-invasive fetal RHD genotyping tests : a systematic review of the quality of reporting of diagnostic accuracy in published studies [PDF]

, 2009
Articles reporting the diagnostic accuracy of non-invasive prenatal diagnostic (NIPD) tests for RHD genotyping using fetal material extracted from maternal blood have been published steadily for over a decade. Health care providers in Europe have started
Szczepura, Ala, Freeman, K., Osipenko, L., Osipenko, Leeza, Freeman, Karoline, Szczepura, Ala; id_orcid   +5 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Characterization of the Mobilome of Invasive Non-typhoidal Salmonella Dublin

, 2019
Title: Characterization of the mobilome of invasive non-typhoidal Salmonella Dublin Authors: Manal Mohammeda, Sabrina Cadel-Sixb,c, Marie-Leone Vignaudb,c, Myron M. Levined aSchool of Life Sciences, University of Westminster, London, UK.
Mohammed, M.
core  

Non invasive

Egyptian Journal of Chest Disease and Tuberculosis, 2013
Background: A combination of early extubation and non invasive positive pressure ventilation is a good alternative for weaning from invasive ventilation in COPD patients. Objective: To evaluate the effectiveness of non invasive ventilation as a weaning method in COPD patients on mechanical ventilation in comparison to the conventional mode ...
Wafaa S. El-Shimy, Mohammad A. Barima, Gehan H. Abo El-Magd, Samar A. Mansour   +3 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Non-invasive investigation of local skin chemistry [PDF]

, 2018
Local skin chemistry was investigated in human participants using non-invasive approaches to characterise volatile organic compounds, cutaneous pH and tissue dielectric constants (TDC).
Jacobs, Matthew, Duffy, Emer, Morrin, Aoife   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source