Results 141 to 150 of about 14,021,594 (346)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Elevated Peripheral CD161+ Treg Cells and Their Clinical Significance in Behçet Syndrome

ACR Open Rheumatology
Objective Behçet syndrome (BS) is a systemic autoimmune vasculitis characterized by immune dysregulation involving multiple immune cell subsets. CD161+ Treg cells exhibit proinflammatory properties and impair immune regulation during inflammation.
Jiachen Li, Weiyi Xia, Feng Sun, Yingni Li, Yuke Hou, Huanhuan Ren, Xiaolin Sun, Yuhui Li, Zhanguo Li, Tian Liu   +9 more
doaj   +1 more source

High-Throughput Analysis Reveals Seasonal Variation of the Gut Microbiota Composition Within Forest Musk Deer (Moschus berezovskii)

Frontiers in Microbiology, 2018
The gut microbiota plays a key role in the nutritional ecology of ruminants, and host diet has a significant effect on these microbial communities. Longitudinal studies assessing variation of seasonal microbiota in animals can provide a comparative ...
Xiaolong Hu, Xiaolong Hu, Gang Liu, Yimeng Li, Yuting Wei, Yuting Wei, Shaobi Lin, Shuqiang Liu, Yunlin Zheng, Defu Hu   +9 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Training Profiles, Efficacy Perceptions, and Outcomes of Non-Invasive Neuromodulation: An Exploratory Study Among Practitioners

Psychiatry International
Advances in non-invasive neuromodulation (NM) have enabled practitioners to modulate neural activity safely, offering a promising approach to treating neuropsychiatric and neurological conditions.
Laura Oliveira Campos, Bianca Rossi Botim, Mayra Evelise Cunha, Denys Batista Campos, Michelle Almeida Barbosa, Gabriela Lopes Gama, Alexandre Carvalho Barbosa   +6 more
doaj   +1 more source

Wave intensity analysis: A novel non-invasive method for determining arterial wave transmission [PDF]

, 2002
Wave intensity analysis is a novel technique for assessing wavelet transmission in the cardiovascular system. Using this tool, we have developed non-invasive techniques to study wave transmission in both central & peripheral arteries in man.
Byrd, SM, Hughes, AD, Khir, AW, Parker, KH, Thom, SAM, Zambanini, A   +5 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Do Progressive Intensities of Transcranial Direct Current Stimulation with and Without 40 Hz Binaural Beats Change Pre-Frontal Cortex Hemodynamics? A Randomized Controlled Trial

Behavioral Sciences
Transcranial direct current stimulation (tDCS) is often reported to have positive effects on brain hemodynamics as well as cognitive performance. Binaural beats (BBs) have also shown the potential to improve cognitive performance.
Maria de Cassia Gomes Souza Macedo, Kariny Realino do Rosário Ferreira, Paula Almeida Meira, Arthur Ferreira Esquírio, Michelle Cristina Sales Almeida Barbosa, Gabriela Lopes Gama, Alexandre Wesley Carvalho Barbosa   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma

Gut, 2018
Objective To characterise gut microbiome in patients with hepatocellular carcinoma (HCC) and evaluate the potential of microbiome as non-invasive biomarkers for HCC.
Z. Ren, Ang Li, Jianwen Jiang, Lin Zhou, Zujiang Yu, Haifeng Lu, Haiyang Xie, Xiaolong Chen, Li Shao, Ruiqing Zhang, Shao-Yan Xu, Hua Zhang, G. Cui, Xinhua Chen, R. Sun, Hao Wen, J. Lerut, Q. Kan, Lanjuan Li, Shusen Zheng   +19 more
semanticscholar   +1 more source