Results 131 to 140 of about 2,756,582 (315)

Non-Invasive Continuous Glucose Monitoring: Identification of Models for Multi-Sensor Systems [PDF]

, 2013
Diabetes is a disease that undermines the normal regulation of glucose levels in the blood. In people with diabetes, the body does not secrete insulin (Type 1 diabetes) or derangements occur in both insulin secretion and action (Type 2 diabetes).
Zanon, Mattia
core  

Surveillance of invasive pneumococcal disease in 30 EU countries: Towards a European system?

, 2010
In this era of new pneumococcal conjugate vaccines (PCV), we described and compared surveillance of invasive pneumococcal disease (IPD) and PCV policies in 30 European countries to provide guidance for Europe-wide surveillance.
Perrocheau, Anne, Celentano, Lucia Pastore, Stuart, James, de Greeffk, Sabine C, Kissling E, Lévy-Bruhl, Daniel, ECDC Country Experts for Pneumococcal Disease, Celentano LP, de Greeff, Sabine C, Tarragó, David, Stefanoff P, Amato-Gauci A, Kriz, Paula, Heuberger, Sigrid, Amato-Gauci, Andrew, Bruhl DL, Tarragó D, de Greef SC, Kriz P, Hanquet G, Kissling, Esther, ECDC country experts for pneumococcal disease, incl., Vergison A, Hanquet, Germaine, Stefanoff, Pawel, Heuberger S, Vergison, Anne, Bruhl, Daniel Levy, Perrocheau A, de Greeff, Sabine C., Stuart J, Mühlemann, Kathrin   +31 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Germination performance of native and non-native Ulmus pumila populations

, 2012
Germination is a crucial step for invasive plants to extend their distribution under different environmental conditions in a new range. Therefore, information on germination characteristics of invasive plant species provides invaluable knowledge about ...
Wehrden, Henrik von,, Hirsch,Heidi, Daniel Renison, Isabell Hensen, Hirsch, Heidi, Renison,Daniel, Renison, Daniel, Catherina Wypior, Hensen, Isabell, von Wehrden,Henrik, Karsten Wesche, Wesche, Karsten, Henrik von Wehrden, Hensen,Isabell, Wypior,Catherina, Wesche,Karsten, von Wehrden, Henrik, Wypior, Catherina, Heidi Hirsch, Wehrden, Henrik von   +19 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype

, 2009
Whereas most nontyphoidal Salmonella (NTS) are associated with gastroenteritis, there has been a dramatic increase in reports of NTS-associated invasive disease in sub-Saharan Africa. Salmonella enterica serovar Typhimurium isolates are responsible for a
Clarke, L., Molyneux, M., Molyneux, Malcolm, MacLennan, CA, Molyneux, Malcom E., Gordon, M. A., Kariuki, Samuel, Cormican, M., Parkhill, J, Holt, Kathryn E., Thomson, N., Kingsley, Robert, Harris, D., Whitehead, Sally, Heyderman, R., Kariuki, S., Thomson, N. R., MacLennan, Calman A., Whitehead, S., Achtman, Mark, Sangal, V, Molyneux, ME, Msefula, CL, Sangal, V., Marsh, K., Holt, K. E., Kariuki, S, Thomson, Nicholas R., MacLennan, Calman, Clarke, L, Achtman, M., Gordon, Melita A., MacLennan, C. A., Holt, Kathryn, Gordon, M., Heyderman, R. S., Dougan, G., Gordon, Melita, Sangal, Vartul, Holt, K., Msefula, C., Msefula, Chisomo, Cormican, Martin, Holt, KE, Parkhill, J., Kingsley, R., Msefula, C. L., Msefula, Chisomo L., Marsh, K, Kingsley, RA, Kingsley, Robert A., Dougan, Gordon, Kingsley, R. A., Parkhill, Julian, Gordon, MA, Thomson, Nicholas, Whitehead, S, Harris, D, Molyneux, M. E., Heyderman, RS, Heyderman, Robert S., Harris, David, Marsh, Kevin, MacLennan, C., Clarke, Louise, Dougan, G, Heyderman, Robert, Thomson, NR, Achtman, M, Cormican, M   +69 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Non-Invasive Analysis of Actinic Keratosis before and after Topical Treatment Using a Cold Stimulation and Near-Infrared Spectroscopy. [PDF]

Medicina (Kaunas), 2020
Seoni S, Savoia P, Veronese F, Zavattaro E, Tarantino V, Meiburger KM.   +5 more
europepmc   +1 more source