Results 121 to 130 of about 2,756,582 (315)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Performance Analysis of Non-invasive Biomarkers in the Treatment of Eosinophilic Oesophagitis
European Medical Journal Allergy & ImmunologyIntroduction: Eosinophilic oesophagitis (EoE) is an emerging disease of the oesophagus. However, so far there are no fully validated biomarkers for diagnosis and monitoring.
Emilio Narváez-Fernández +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Non-invasive biomedical analysis
Non-invasive healthcare technologies are increasingly pivotal in research anddevelopment due to their affordability and the convenience they offer to bothhealthcare recipients and providers. Alongside traditional non-invasive methodssuch as ultrasound imaging, a variety of innovative non-invasive devices havebeen developed. These include cardiovascular
openaire +3 more sources
Analysis of the Course of Non-Invasive Pulmonary Aspergillosis.
Nippon Ishinkin Gakkai Zasshi, 1997 一般的に言って,非侵襲性肺アスペルギローシスは,その経過の長さや自覚症の乏しさから非活動的であり,静的な病態として把握されている.このような見地から,近年,比較的急速に進展する病態に対して“Semi-Invasive Pulmonary Aspergillosis”や“Chronic Necrotizing Pulmonary Aspergillosis”等の新しい疾患呼称が定型的aspergillomaに対置する形で,提唱されてきた.しかし,これらの新たな疾患呼称は,不十分な定義から臨床現場に用語の混乱や不適切な適用をもたらしている.また,この定型的aspergillomaそのものの進展経過,成立過程も未だ十分に検討されているとは言えない.我々は ...
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source