Results 101 to 110 of about 34,275,912 (300)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas

Frontiers in Endocrinology, 2017
ACTH-dependent hypercortisolism caused by a pituitary adenoma [Cushing’s disease (CD)] is the most common cause of endogenous Cushing’s syndrome. CD is often associated with several morbidities, including hypertension, diabetes, osteoporosis/bone ...
Leonardo Jose Tadeu de Araújo, Leonardo Jose Tadeu de Araújo, Antonio Marcondes Lerario, Antonio Marcondes Lerario, Margaret de Castro, Clarissa Silva Martins, Marcello Delano Bronstein, Marcello Delano Bronstein, Marcio Carlos Machado, Marcio Carlos Machado, Marcio Carlos Machado, Ericka Barbosa Trarbach, Maria Candida Barisson Villares Fragoso, Maria Candida Barisson Villares Fragoso   +13 more
doaj   +1 more source

Improving Invasive Animal Institutions: A citizen-focused approach. A citizen-focused review of institutional arrangements for Invasive Animal management

, 2014
This report discusses rules and responsibilities, property rights, administration, funding and management and other 'institutional' issues that affect landholders, volunteers, businesses, community groups or other non-government organisations (NGO's ...
Martin, Paul, Marshall, Graham R, Le Gal, Elodie, Dickson, Katrina, Low Choy, Darryl   +4 more
core  

The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017 [PDF]

, 2019
Background: Non-typhoidal salmonella invasive disease is a major cause of global morbidity and mortality. Malnourished children, those with recent malaria or sickle-cell anaemia, and adults with HIV infection are at particularly high risk of disease ...
Bassat Orellana, Quique, GBD 2017 Non-Typhoidal Salmonella Invasive Disease Collaborators   +1 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Welcome to InvasiveSpecies.gov!

, 2011
This website contains information about the purpose and work of the National Invasive Species Council, including its plans to prevent and manage invasive species, educational materials, budgetary and organizational documents of the Council, and other ...
National Invasive Species Council (U.S.)
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Unusual Composition of the Sarezzano Reliquary Busts

Heritage
The interdisciplinary study of two reliquary busts from Sarezzano (Piedmont, Italy) is a perfect example of the necessity to provide for material characterisation as a recurring common practice in historical studies and a mandatory step in conservation ...
Maria Labate, Carmela Sirello, Maurizio Aceto, Fulvio Cervini, Simonetta Castronovo, Lorenza Operti, Angelo Agostino   +6 more
doaj   +1 more source

Non invasive methods for genetic analysis applied to ecological and behavioral studies in Latino-America

Revista Brasileira de Zootecnia, 2007
Documenting the presence and abundance of the neotropical mammals is the first step for understanding their population ecology, behavior and genetic dynamics in designing conservation plans.
Susana González, José Mauricio Barbanti Duarte   +1 more
doaj   +1 more source

The Economic Impacts of Vertebrate Pests in Australia

, 2009
Invasive animal pests have a wide variety of impacts on the economy, the environment and society. There is considerable information on these impacts for individual cases and regions, and McLeod (2004) attempted to value them nationwide for a whole range ...
Sinden, Jack A, Jones, Randall, Sinden, Jack, Braysher, Mike, Gong, Wendy, Braysher, Michael   +5 more
core