Results 81 to 90 of about 1,612,607 (331)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Concomitant Carcinoma in situ in Cystectomy Specimens Is Not Associated with Clinical Outcomes after Surgery [PDF]

, 2011
Objective: The aim of this study was to externally validate the prognostic value of concomitant urothelial carcinoma in situ (CIS) in radical cystectomy (RC) specimens using a large international cohort of bladder cancer patients. Methods: The records of
Colin P. Dinney, Derya Tilki, Eila Skinner, Francesco Montorsi, Giacomo Novara, Guru Sonpavde, Habuchi T, Hans-Martin Fritsche, Hendrik Isbarn, Jonathan I. Izawa, Knowles MA, Lamm DL, Patrick J. Bastian, Philipp Nuhn, Pierre I. Karakiewicz, Robert S. Svatek, Rosin MP, Sarkis AS, Shahrokh F. Shariat, Skinner DG, Spruck, Stefan C. Müller, Utz DC, Vincenzo Ficarra, Wassim Kassouf, Yves Fradet, Zincke H   +26 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Rates of margin positive resection with breast conservation for invasive breast cancer using the NCDB

Breast, 2021
Background: Previous studies suggest the rate of positive surgical margin (PSM) after lumpectomy for breast cancer is approximately 20 %. The risk of PSM at time of resection is often a source of fear for patients, driving some to elect to undergo ...
Hotsinpiller WJ, Everett AS, Richman JS, Parker C, Boggs DH   +4 more
doaj   +1 more source

Celebrity worship and incidence of elective cosmetic surgery: evidence of a link among young adults. [PDF]

, 2011
Purpose: The purpose of the current study was to explore among young adults whether celebrity worship predicted the incidence of elective cosmetic surgery within the period of 8 months after controlling for several known predictors of elective cosmetic
Day, Liza, Maltby, J
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Non-invasive assessment prior to invasive coronary angiography in routine clinical practice in Switzerland - Is it according to the guidelines?

PLoS ONE, 2019
BACKGROUND:Non-invasive testing is recommended as a basis to decide about the indication for invasive coronary angiography (ICA) in patients with suspected stenotic coronary artery disease (CAD).
Rebecca Schiefer, Hans Rickli, Evelyne Neurauter, Marc Buser, Daniel Weilenmann, Micha T Maeder   +5 more
doaj   +1 more source

Polyscore of Non-invasive Cardiac Risk Factors

Frontiers in Physiology, 2019
Non-invasive risk stratification of cardiac patients has been the subject of numerous studies. Most of these investigations either researched unique risk predictors or compared the predictive power of different predictors.
Alexander Steger, Alexander Müller, Petra Barthel, Michael Dommasch, Katharina Maria Huster, Katerina Hnatkova, Daniel Sinnecker, Alexander Hapfelmeier, Marek Malik, Georg Schmidt   +9 more
doaj   +1 more source

Safety and efficacy of endoscopic submucosal dissection for rectal neoplasia: a multicenter North American experience. [PDF]

, 2019
Background and aims  Rectal lesions traditionally represent the first lesions approached during endoscopic submucosal dissection (ESD) training in the West. We evaluated the safety and efficacy of rectal ESD in North America.
Aadam, Abdul Aziz, Aihara, Hiroyuki, Andrawes, Sherif, Benias, Petros, Chang, Kenneth, Diehl, David L, Draganov, Peter V, Hashimoto, Rintaro, Hwang, Joo Ha, Inamdar, Sumant, Khara, Harshit S, Khashab, Mouen A, Khoshknab, Milad Pourmousavi, Kim, Raymond E, Kumta, Nikhil A, Lan, Gloria, Maniere, Thibaut, Natov, Nikola S, Ngamruengphong, Saowanee, Nosler, Michael J, Othman, Mohamed O, Perbtani, Yaseen B, Ramay, Fariha, Samarasena, Jason, Sethi, Amrita, Siegel, Amanda, Tabash, Abdalaziz, Tharian, Benjamin, Tomizawa, Yutaka, Wang, Andrew Y, Yang, Dennis, Zou, Baiming   +31 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source