Results 101 to 110 of about 1,612,607 (331)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Invasive and non-invasive variables prediction models for cardiovascular disease-specific mortality between machine learning vs. traditional statistics

Scientific Reports
This study examined the predictive performance of cardiovascular disease (CVD)-specific mortality using traditional statistical and machine learning models with non-invasive indicators, and assessed whether adding blood lipid profiles improves prediction.
Seonggyu Choi, Minsuk Oh, Dong Hoon Lee, Sun Ha Jee, Justin Y. Jeon   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

ANALYSIS OF IMMUNITY IN OSTEOSARCOMA AS A BASIS FOR DEVELOPMENT FOLLOWING THERAPY

Journal Orthopaedi and Traumatology Surabaya, 2019
Background: Osteosarcoma is a malignant bone disease. Predictors which used to determine osteosarcoma from non-invasive (stage IIB) to invasive (stage III), through the ratio of macrophages-1 (M-1) which are pro-inflammatory (anti-cancer) with ...
Ferdiansyah Mahyudin, Mouli Edward, Muhammad Hardian Basuki, Kadek Seta Prawira   +3 more
doaj   +1 more source

A Roadmap for Integrating Neuroscience into Addiction Treatment:A Consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine [PDF]

, 2019
Although there is general consensus that altered brain structure and function underpins addictive disorders, clinicians working in addiction treatment rarely incorporate neuroscience-informed approaches into their practice.
Arunogiri, Shalini, Baldacchino, Alex, Bates, Marsha E., Bowden-Jones, Henrietta, Bruno, Raimondo, Campanella, Salvatore, Daughters, Stacey, Ekhtiari, Hamed, Hester, Rob, Kouimtsidis, Christos, Lorenzetti, Valentina, Lubman, Dan I., Manning, Victoria, Meyerhoff, Dieter J., Moeller, Scott J., Paulus, Martin P., Pennington, David, Piercy, Hugh, Ralph, Annaketurah, Rezapour, Tara, Steele, Douglas, Tavakoli, Hosna, Tolomeo, Serenella, Verdejo-Garcia, Antonio, Zare-Bidoky, Mehran, Zilverstand, Anna   +25 more
core   +8 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A novel stepwise micro-TESE approach in non obstructive azoospermia [PDF]

, 2016
Background: The purpose of the study was to investigate whether micro-TESE can improve sperm retrieval rate (SRR) compared to conventional single TESE biopsy on the same testicle or to contralateral multiple TESE, by employing a novel stepwise micro ...
Casciani, V, DE NUNZIO, Cosimo, Dente, Donato, Franco, Giorgio, Greco, Alessia, Greco, E., Greco, Pf, Leonardo, Costantino, Minasi, Mg, Scarselli, F   +9 more
core   +2 more sources

Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome

Indian Journal of Medical Research, 2020
Background & objectives: There is limited data on non-alcoholic fatty liver disease (NAFLD) among Indian women with polycystic ovary syndrome (PCOS), and there are no data on the utility of fibroscan in its assessment. The objective of this study was thus to investigate the frequency of hepatic steatosis in young women with
Chakraborty, Semanti, Ganie, Mohd Ashraf, Masoodi, Ibrahim, Jana, Manisha, Shalimar,, Gupta, Nandita, Sofi, Nighat Yaseen   +6 more
openaire   +2 more sources

Clinical and Laboratory Predictors for Plaque Erosion in Patients With Acute Coronary Syndromes

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019
Background Plaque erosion is responsible for 25% to 40% of patients with acute coronary syndromes (ACS). Recent studies suggest that anti‐thrombotic therapy without stenting may be an option for this subset of patients.
E. Yamamoto, T. Yonetsu, T. Kakuta, Tsunenari Soeda, Yoshihiko Saito, B. Yan, O. Kurihara, M. Takano, G. Niccoli, T. Higuma, S. Kimura, Y. Minami, J. Ako, T. Adriaenssens, N. Boeder, H. Nef, F. Fracassi, T. Sugiyama, Hang Lee, F. Crea, Takeshi Kimura, J. Fujimoto, V. Fuster, I. Jang   +23 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source