Results 41 to 50 of about 3,704 (266)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Isolated Multi-Port DC-DC Converters for Renewable Energy Sources: A Review

IEEE Access
Multi-port DC-DC converters (MPCs) become increasingly popular in power conversion for renewable energy sources (RESs), battery storage systems (BSSs), and electric vehicles (EVs).
Alireza Asadi, Xiaodong Liang, Sobhan Sarani, Mohammad Saleh Karimzadeh   +3 more
doaj   +1 more source

Review on non-isolated DC-DC converters and their control techniques for renewable energy applications

Ain Shams Engineering Journal, 2021
In recent times, the need for energy consumption is drastically increasing to fulfill the global requirements of commercial and domestic consumer demands.
Farhan Mumtaz, Nor Zaihar Yahaya, Sheikh Tanzim Meraj, Balbir Singh, Ramani Kannan, Oladimeji Ibrahim   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Study of a non‐isolated bidirectional DC–DC converter

IET Power Electronics, 2013
The study presents a non‐isolated bidirectional DC–DC converter, which has simple circuit structure. The control strategy is easily implemented. Also, the synchronous rectifier technique is used to reduce the losses. The voltage gain of the proposed converter is the half and the double of the conventional bidirectional DC–DC buck/boost converter in the
C.‐C. Lin, L.‐S. Yang, G.W. Wu
openaire   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Review, Properties, and Synthesis of Single-Switch Non-Isolated DC-DC Converters with a Wide Conversion Range

Sensors
The cascaded connection of power converters extends conversion ranges but requires careful consideration due to high component count and efficiency concerns, as power is processed redundantly.
Fernando Lessa Tofoli, Thaís Martins Jajah Carlos, Aniel Silva Morais   +2 more
doaj   +1 more source