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Immunohistochemical Expression of Langerin in Langerhans Cell Histiocytosis and Non-Langerhans Cell Histiocytic Disorders

American Journal of Surgical Pathology, 2008
Langerin is a type II transmembrane C-type lectin associated with the formation of Birbeck granules in Langerhans cells. Langerin is a highly selective marker for Langerhans cells and the lesional cells of Langerhans cell histiocytosis. Although Langerin protein expression in Langerhans cell histiocytosis has been previously documented, the specificity
Sean K, Lau   +2 more
openaire   +2 more sources

Suprasellar non-Langerhans cell histiocytosis (Erdheim–Chester disease)—a case report

Clinical Imaging, 2013
Erdheim-Chester disease (ECD) is an uncommon non-Langerhans cell histiocytosis that affects multiple body systems and can present clinically in a myriad of ways. An adult onset is most common with bony involvement and constitutional symptoms. We report the case of a 52-year-old female presenting with diabetes insipidus and a suprasellar mass on imaging,
Manas, Sharma   +3 more
openaire   +2 more sources

Efficacy and Tolerance of Cladribine for Non‐Langerhans Cell Histiocytosis

European Journal of Haematology
ABSTRACT Background Erdheim‐Chester Disease ( ECD ) and Rosai‐Dorfman Disease ( RDD ) Are Rare Non‐Langerhans Cell Histiocytoses That Share Several Clinical and Histological Features ...
Quentin Riller   +15 more
openaire   +1 more source

GENERALIZED NON‐LANGERHANS CELL HISTIOCYTOSIS: FOUR CASES ILLUSTRATE A SPECTRUM OF DISEASE

International Journal of Dermatology, 1995
Abstract Background. The proliferation of non‐Langerhans cell histiocytes is a poorly understood process of unknown cause. Variation in the clinical features and/or histopathology of histiocytic proliferation has led to subclassification of the general category of non‐Langerhans cell histiocytes.
E A, Mullans   +5 more
openaire   +2 more sources

Intracranial findings of Non-Langerhans-Cell Histiocytosis

2019
Learning objectives Background Findings and procedure details Conclusion Personal information ...
openaire   +1 more source

A unique non-Langerhans cell histiocytosis with some features of generalized eruptive histiocytoma

Journal of the American Academy of Dermatology, 1994
A symmetric eruption of hundreds of coalescent small red macules and a few slightly elevated papules sparing the flexures was observed in a 73-year-old man. Light microscopic examination showed loose aggregates of small and large histiocytic cells. Electron microscopy showed an absence of Langerhans cell granules and lipid droplets.
S, Goerdt   +5 more
openaire   +2 more sources

Lymphocyte sub-populations and non-Langerhans’ cell monocytoid cells in pulmonary Langerhans’ cell histiocytosis

Pathology - Research and Practice, 2008
Pulmonary Langerhans' cell histiocytosis (PLCH) is a disease characterized by the occurrence of complex fibro-cellular interstitial lesions dominated by Langerhans' cells (LC), which occurs predominantly in young adult smokers. We undertook this retrospective study to better define the lymphohistiocytic cell populations in PLCH in order to obtain a ...
R, Nagarjun Rao   +2 more
openaire   +2 more sources

Diffuse xanthogranulomatous dermatitis and systemic Langerhans cell histiocytosis: A novel case that demonstrates bridging between non-Langerhans cell histiocytosis and Langerhans cell histiocytosis

Journal of the American Academy of Dermatology, 2009
The advent of electron microscopy and immunohistochemical stains allowed for reclassification of the histiocytoses based on the predominant cell in the infiltrate. Although the current schema simplicity provides a good foundation, some patients display overlapping clinical and immunohistochemical features that defy classification.
Elizabeth K, Satter   +2 more
openaire   +2 more sources

Non-Langerhans cell histiocytosis associated with lymphocyte-predominant Hodgkin's disease

Clinical and Experimental Dermatology, 1999
We report a 74-year-old man who presented with a rash on the trunk showing clinical and histological features of non-Langerhans cell histiocytosis. Two years after presentation he developed weight loss, lymphadenopathy and hepatosplenomegaly; a diagnosis of lymphocyte-predominant Hodgkin's disease was made on lymph node biopsy.
null Ibbotson   +3 more
openaire   +4 more sources

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