Results 51 to 60 of about 23,888 (239)

Cutaneous Rosai‐Dorfman Disease With MAP2K1 Mutation Treated With Encorafenib and Binimetinib

JEADV Clinical Practice, EarlyView.
ABSTRACT Rosai‐Dorfman disease (RDD) is a rare histiocytic disorder with unifocal to multisystemic involvement. Activating mutations in the MAPK/ERK pathway can occur in up to 50% of RDD cases. We report a case of cutaneous RDD (C‐RDD) with facial and truncal lesions harboring an activating MAP2K1 (MEK1) mutation that showed a complete response to a ...
Melike Ak, Reinhard Dummer, Egle Ramelyte   +2 more
wiley   +1 more source

Solving a Mystery . . . 8 Years Later

Journal of Investigative Medicine High Impact Case Reports, 2018
Erdheim-Chester disease is a rare non-Langerhans cell histiocytosis with multisystem involvement and insidious symptoms. In this article, we describe an interesting case of Erdheim-Chester disease that was eventually diagnosed 8 years after symptoms ...
Hayan Jouni MD, Ronald S. Kuzo MD, Nandan S. Anavekar MBBCh   +2 more
doaj   +1 more source

Eosinophilic Granuloma: A Rare and Often Benign Condition Presenting as a Lump on the Head, which was Easily Treated

European Journal of Case Reports in Internal Medicine, 2021
Eosinophilic granuloma is a localized, non-invasive form of Langerhans cell histiocytosis. It usually develops in the long bones and is more frequent in children under the age of 10 years. It is very rare in adults.
Tatiana Pires, Catarina Duarte Santos, Miguel Gonzalez Santos, Luís Luz, Ana Ferrão, Maria J. Banza   +5 more
doaj   +1 more source

Next‐Generation Paleopathology: Using Commercial AI in Bioarchaeological Diagnosis

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Artificial intelligence encompasses computational systems capable of performing cognitive functions such as learning, reasoning, and problem‐solving. Within this domain, generative AI and large language models such as ChatGPT, Gemini, and Copilot have shown significant potential in clinical diagnostics.
Jessica Mongillo, Giulia Vescovo, Giulia Manzo, Nicoletta Zedda, Barbara Bramanti   +4 more
wiley   +1 more source

Extraosseous langerhans cell histiocytosis in children

, 2008
Langerhans cell histiocytosis, a rare disease that occurs mainly in children, may produce a broad range of manifestations, from a single osseous lesion to multiple lesions involving more than one organ or system.
Letovanec, I., Geoffray, A., Letovanec, Igor, Waibel, Peter, Georg Eich, Peter Waibel, Schmidt, S., Gudinchet, Francois, Hanquinet, Sylviane, Eich, Georg, Anne Geoffray, Wolf, R., Rainer Wolf, Sabine Schmidt, Geoffray, Anne, Hanquinet, S., Schmidt, Sabine, Alamo-Maestre, L., Francois Gudinchet, Alamo-Maestre, Leonore, Eich, G., Gudinchet, F., Igor Letovanec, Leonore Alamo-Maestre, Waibel, P., Wolf, Rainer, Sylviane Hanquinet   +26 more
core   +1 more source

Uncommon preputial localization of Langerhans cell histiocytosis

, 2021
International audienceWe report a rare case of a 14-year-old boy with Langerhans cell histiocytosis localized to the prepuce. The patient was treated with a topical corticosteroid followed by imiquimod cream resulting in significant clinical improvement ...
Sebastien Barbarot, Petrot, Dominique, Dominique Petrot, Barbarot, Sébastien, Thomas, Caroline, Clemence Mesnard, Fraitag, Sylvie, Legroux, Jacques, Caroline Thomas, Sylvie Fraitag, Jacques Legroux, Mesnard, Clemence   +11 more
core   +1 more source

Multicentric reticulohistiocytosis: a case report

BMC Research Notes, 2018
Background Multicentric reticulohistiocytosis is a rare form of non-langerhans cell histiocytosis presenting with skin changes and erosive arthritis. Infiltration of histiocytes and multinucleated giant cells are typical histological findings and confirm
Azadèh Farokhi, Richard M. van Vugt, Rick Hoekzema, Michael T. Nurmohamed   +3 more
doaj   +1 more source

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, EarlyView.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source

[Unusual pulmonary presentation of systemic Langerhans cell histiocytosis]

, 2008
An 80-year-old nonsmoking man was referred to our hospital with bilateral perihilar pulmonary opacities. He had a history of epilepsy, sclerosing cholangitis, cutaneous lesions previously diagnosed as localised Langerhans cell histiocytosis.
Schuller, A, Lega, J-C, Schuller, Aurélien, Lazor, R, Lega, Jean-Christophe, Cottin, Vincent, Cordier, J F, Cordier, Jean-François, Jullien, D, Lazor, Romain, Jullien, Denis, Cottin, V   +11 more
core   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source