Results 41 to 50 of about 7,086 (183)

Extraintestinal Manifestation of Crohn's Disease in the Middle Ear—A Case Report

The Laryngoscope, EarlyView.
A unique clinical case with extraintestinal manifestation of Crohn's disease in the middle ear, causing severe inflammation and troublesome symptoms. The combination of systemic therapy and surgery curbed the middle ear manifestation upon diagnosis.
Julia Arebro
wiley   +1 more source

MEK Inhibition with Trametinib in Patients with Non-Langerhans Cell Histiocytosis

Blood, 2019
Background: Activation of the MAPK pathway through BRAF mutations or other molecular alterations is a hallmark of the non-Lagerhans cell histiocytosis (non-LCH) such Erdheim-Chester disease (ECD) or Rosai-Dorfman disease (RDD). Conventional clinical molecular testing of tumor tissue fails to identify targetable molecular alteration in about one third ...
Filip Janku, Harsh Patel, Vaijayanthi Kandadai Raghavan, Aaron Goodman, Tamara G. Barnes, Razelle Kurzrock   +5 more
openaire   +1 more source

Precision immunomodulation for pediatric hemophagocytic lymphohistiocytosis in intensive care

Pediatric Investigation, EarlyView.
This review presents a bedside framework for recognizing pediatric hemophagocytic lymphohistiocytosis and cytokine storm, stabilizing organ dysfunction, identifying the underlying phenotype, selecting targeted immunomodulation, considering extracorporeal adjuncts, and reassessing response within 24–72 h. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH)
Weerapong Lilitwat, Prakreeti Bhandari
wiley   +1 more source

Indeterminate Cell Histiocytosis: Report of a Case

Acta Medica Iranica, 2014
Indeterminate cell histiocytosis is a very rare disorder of histiocytes proliferation. It has both Langerhans and non-Langerhans cell histiocytosis immunophenotypic features.
Alireza Ghanadan, Kambiz Kamyab, Mazaher Ramezani, Azadeh Goodarzi, Maryam Daneshpajouh, Kamran Balighi, Mahsa Ansari, Seyyed Farzad Mirfallah Nassiri, Soroush Daklan   +8 more
doaj  

Pregnancy in CTD‐interstitial lung disease: Current evidence, clinical challenges, and a proposed management algorithm

Rheumatology &Autoimmunity, EarlyView.
Summary of pregnancy management in CTD‐ILD across preconception, antenatal, and postpartum phases, emphasizing risk stratification and multidisciplinary care. 6MWT, 6‐min walk test; CTD‐ILD: connective tissue disease‐interstitial lung disease; DLCO, diffusion capacity of the lung for carbon monoxide; FVC, forced vital capacity; MDT, multidisciplinary ...
Khaled Aldhuaina, Ghaydaa Aldabie, Mohammad Abdulsalam, Ali Jawad   +3 more
wiley   +1 more source

CT‐Based Biomarkers for Predicting Progressive Phenotypes in Interstitial Lung Diseases: A Retrospective Cohort Study

Respirology, EarlyView.
This study demonstrates that the Single Time Point Prediction score, a novel machine learning–based imaging biomarker, along with established quantitative CT measures, is significantly associated with disease progression in non‐IPF ILD. This imaging metric may enable earlier identification of high‐risk patients and support personalised treatment ...
Ju Hyun Oh, Jin Woo Song, Jonathan Goldin, S. Samuel Weigt, Augustine Chung, Jared D. Wilkinson, Fereidoun Abtin, Lila Pourzand, Bianca Villegas, Jihey Lee, Kyungjong Lee, Grace Hyun J. Kim   +11 more
wiley   +1 more source

The clinicopathological characteristics and differential diagnosis of histiocytosis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
The histiocytosis is divided into Langerhans' cell histiocytosis (histiocytosis X) and non-Langerhans' cell histiocytosis (NLCH). The former mainly occurs in lymphatic hematopoietic tissue and often involves central nervous system (CNS).
Shi-zhu YU
doaj  

Indeterminate Cell Histiocytosis in Association with Acute Myeloid Leukemia

Dermatology Research and Practice, 2010
Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder, in which the predominant cells share morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytosis. We describe a 62-year-old man presenting a
Filipa Ventura, Teresa Pereira, Maria da Luz Duarte, Herlander Marques, Fernando Pardal, Celeste Brito   +5 more
doaj   +1 more source

Solitary Indeterminate Cell Histiocytosis Presenting as a Reddish Nodule on the Abdomen of a 4‐Year‐Old Boy: Clinicopathologic Correlation and Electron Microscopy Findings

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Indeterminate cell histiocytosis (ICH) is a clonal proliferative disorder of mononuclear phagocyte cells that shows features of both dendritic and histiocytic cells. Only around 100 cases of ICH were reported, and among them, only 24% of reported cases involve pediatric patients, with a mean age at diagnosis of 50 years.
Seung‐Soo Lee, Seok‐Jong Lee, Weon Ju Lee, Dae‐Lyong Ha   +3 more
wiley   +1 more source

Scabies mimicking mastocytosis in two infants

The Turkish Journal of Pediatrics, 2013
Scabies is a common parasitic human infection in infants and children. However, diagnostic pitfalls are frequent in infants, in whom the clinical presentation is usually atypical and different from that in adults.
Emine Cölgeçen-Özel, Ragıp Ertaş, Serap Utaş, Olgun Kontaş   +3 more
doaj