Results 121 to 130 of about 603,480 (300)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Credibility Distribution Estimation with Weighted or Grouped Observations

Risks
In non-life insurance practice, actuaries are often faced with the challenge of predicting the number of claims and claim amounts to be incurred at any given time, which serve to implement fair pricing and reserves given the nature of the risk.
Georgios Pitselis
doaj   +1 more source

Productivity and Technical Efficiency in the Italian Insurance Industry [PDF]

The purpose of this paper is to partially fill the gap in the existing literature by conducting an analysis of technical efficiency and productivity growth in the Italian insurance industry.
Giuseppe Turchetti, J. David Cummins
core  

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

For the Benefit of Our Workers: The Massachusetts Nonprofit Employee Benefit Study [PDF]

, 2009
Analyzes survey results on the types and costs of benefits offered to employees of Massachusetts' large nonprofit institutions, small grassroots organizations, and safety-net organizations.
Elizabeth Keating
core  

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

Small Business: Big Challenge [PDF]

, 2002
In recent years, the contributions of small business to the American economy have become increasingly apparent. Small firms are a significant source of new jobs, and play crucial roles in the development of new technologies and provision of economic ...
Garcia, Ramon
core   +1 more source

Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium‐glucose cotransporter 2 inhibitor users

British Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Active surveillance of adverse events using healthcare data is emerging as complementary to the monitoring of spontaneous reports and stand‐alone pharmacoepidemiologic studies. The risk of urinary tract infections (UTIs) was listed as a special warning for sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) when marketed in Europe
Haoxin Le, Dilsad Simay Peker, Lukas Frederic Westphal, Nikolai Brun, Christine Erikstrup Hallgreen, Morten Andersen   +5 more
wiley   +1 more source

Comparison of the Household Insurance Products and Selection of the Optimal Product [PDF]

, 2014
Import 05/08/2014Cílem bakalářské práce je výběr optimálního produktu pojištění domácnosti pro zvolený subjekt. Práce je rozdělena, mimo úvodu a závěru, do tří částí.
Štverková, Gabriela
core  

Teacher‐makers and teacher‐breakers: (Re)defining how status and safety influence trajectories into and away from teaching

British Educational Research Journal, EarlyView.
Abstract This paper uses empirical data from a longitudinal qualitative study conducted with aspirant teachers in England to propose (re)definitions of the concepts of ‘status’ and ‘safety’ as a framework with which to understand and improve teacher recruitment.
Emily MacLeod
wiley   +1 more source