Results 71 to 80 of about 6,291,274 (347)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

GEOMETRICALLY NON-LINEAR ANALYSIS OF SHELLS

TASK Quarterly, 2006
The work’s aim has been to verify the suitability of commercial engineering software for geometrically non-linear analysis of shell structures. The paper deals with static, geometrically non-linear analysis of shells made of isotropic materials.
ANDRZEJ AMBROZIAK
doaj  

Non-linear susceptibility in glassy systems: a probe for cooperative dynamical length scales

, 2005
We argue that for generic systems close to a critical point, an extended Fluctuation-Dissipation relation connects the low frequency non-linear (cubic) susceptibility to the four-point correlation function.
A. Zippelius, C. Donati, D. Kivelson, E. Vincent, G. J. M. Koper, Giulio Biroli, H. Rieger, J. Cardy, J. P. Bouchaud, J. P. Bouchaud, J.-P. Bouchaud, Jean-Philippe Bouchaud, L. Berthier, L. Cugliandolo, M. Mézard, P. G. Debenedetti, S. Franz, T. Komori, W. Götze, W. Kob   +19 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Pushover Analysis of Steel Seismic Resistant Frames with Reduced Web Section and Reduced Beam Section Connections

Frontiers in Built Environment, 2017
The widespread brittle failure of welded beam-to-column connections caused by the 1994 Northridge and 1995 Kobe earthquakes highlighted the need for retrofitting measures effective in reducing the strength demand imposed on connections under cyclic ...
Daniel Tomas Naughton, Konstantinos Daniel Tsavdaridis, Chrysanthos Maraveas, Andreas Nicolaou   +3 more
doaj   +1 more source

A non-linear analysis of Gibson's paradox in the Netherlands, 1800-2012 [PDF]

, 2014
This paper adopts a multivariate, non-linear framework to analyse Gibson’s paradox in the Netherlands over the period 1800-2012. Specifically, SSA (singular spectrum) and MSSA (multichannel singular spectrum) techniques are used. It is shown that changes
Caporale, Guglielmo Maria, Škare, Marinko   +1 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source