Results 81 to 90 of about 192,638 (268)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Entropy, 2019 This paper discusses the effects of introducing nonlinear interactions and noise-filtering to the covariance matrix used in Markowitz’s portfolio allocation model, evaluating the technique’s performances for daily data from seven financial ...
Yaohao Peng +3 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A Kalman Estimation Based Rao-Blackwellized Particle Filtering for Radar Tracking
IEEE Access, 2017 The Rao-Blackwellized particle filtering (RBPF) offers a general tracking framework with linear/nonlinear state space models, which outperforms the standard particle filtering in nonlinear and non-Gaussian tracking scenarios.
Jingxian Liu, Zulin Wang, Mai Xu
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Robust Student’s T Distribution Based PHD/CPHD Filter for Multiple Targets Tracking Using Variational Bayesian Approach [PDF]
Radioengineering, 2020 Measurement-outliers caused by non-linear observation model or random disturbance will lead to the accuracy decline of a target tracking filter. This paper proposes a robust probability hypothesis density (PHD) filter to handle the measurement-outlier ...
P. Li, C. Xu, W. Wang, S. Su
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Mean-Variance Hedging and Forward-Backward Stochastic Differential Filtering Equations
Abstract and Applied Analysis, 2011 This paper is concerned with a mean-variance hedging problem with partial information, where the initial endowment of an agent may be a decision and the contingent claim is a random variable.
Guangchen Wang, Zhen Wu
doaj +1 more source