Results 231 to 240 of about 508,741 (299)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Synergistic effects of hard anodizing parameters on the microstructural, mechanical, and tribological properties of 6061 aluminum alloy. [PDF]

Sci Rep
Behzadifar J, Najafi Y, Nazarizade B.
europepmc   +1 more source

New design of plate implant for bone healing assessment using frequency measurement: a biomechanical cadaveric study. [PDF]

Sci Rep
Amarase C, Tangpornprasert P, Virulsri C, Chancharoen P, Tantavisut S.   +4 more
europepmc   +1 more source

A novel approach to monitoring selective fatigue in female softball athletes: evaluating load-velocity relationship variables and specific performance metrics. [PDF]

Front Physiol
Zhang H, Li Z, Yu Q, Cheng Z, Wang X, Zhang X, García-Ramos A, Janicijevic D.   +7 more
europepmc   +1 more source

Geometrically nonlinear high-fidelity aerostructural optimization for highly flexible wings. [PDF]

Struct Multidiscipl Optim
Gray AC, Kennedy GJ, Martins JRRA.
europepmc   +1 more source

A time-dependent reliability model for spatial intermittent motion mechanisms via constant-amplitude alternating fatigue load equivalent method. [PDF]

Sci Rep
Cheng P, Zhang T, Zhu Y.
europepmc   +1 more source

The peak shifting electricity consumption management and influencing factors of smart grid from recurrent neural network model and deep learning. [PDF]

Sci Rep
Wang F, Huang D, Lu W.
europepmc   +1 more source