A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Quantifying the temperature-related fraction of hand, foot, and mouth disease using distributed lag non-linear models: lessons from the COVID-19 pandemic period. [PDF]
Front Public HealthRen Y +6 more
europepmc +1 more source
Non-linear error correction, asymmetric adjustment and cointegration. [PDF]
This article links the intertemporal choice model with the non-linear error correction (NEC) model. It has three main components. First, it outlines a model of non-linear error correction, in which the linear error correction term ?Xt (the vector time ...
Pfann, Gerard, Escribano, Álvaro
core
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Modelling growth patterns of three guinea fowl varieties using non-linear models. [PDF]
Poult SciFaraji-Arough H, Dashab GR, Rokouei M.
europepmc +1 more source
Short-term electricity price forecasting with time series models: A review and evaluation [PDF]
We investigate the forecasting power of different time series models for electricity spot prices. The models include different specifications of linear autoregressive time series with heteroscedastic noise and/or additional fundamental variables and non ...
Rafal Weron, Adam Misiorek
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Association between short-term fine particulate matter exposure and hospital-acquired pneumonia risk in critically ill post-cardiac surgery patients: a 10-year cohort study using distributed lag non-linear models. [PDF]
Front Public HealthLi T, Yu Y, Liu C, Liu Z, Tan Q, Li W.
europepmc +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
The comparisons of non-linear models to describe the growth performance of Lori-Bakhtiari sheep. [PDF]
Vet Med SciForoutanifar S, Khaldari M.
europepmc +1 more source