DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Use of the linear regression method to evaluate population accuracy of predictions from non-linear models. [PDF]
Yu H, Fernando RL, Dekkers JCM.
europepmc +1 more source
Non-linear models for the detection of impaired cerebral blood flow autoregulation. [PDF]
Chacón M +4 more
europepmc +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Effects of ambient temperature on pediatric incident seizure: A case-crossover analysis using distributed lag non-linear models. [PDF]
Zhang S +6 more
europepmc +1 more source
Time Hierarchies and Model Reduction in Canonical Non-linear Models. [PDF]
Löwe H, Kremling A, Marin-Sanguino A.
europepmc +1 more source
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
A variety of soliton solutions of time M-fractional: Non-linear models via a unified technique. [PDF]
Roshid MM +3 more
europepmc +1 more source
An evaluation of linear and non-linear models of expressive dynamics in classical piano and symphonic music. [PDF]
Cancino-Chacón CE +3 more
europepmc +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source

