Results 111 to 120 of about 14,727,707 (258)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
An approach to non-linear Bayesian forecasting problems with applications [PDF]
This thesis is devoted to the analysis and modelling of time series and it is concentrated on models and techniques which are of practical value. In particular we developed a wide class of non-linear dynamic models which are useful in the handling of ...
Migon, Helio dos Santos
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2006 The non-linear normal modes (NNMs) and their bifurcation of a complex two DOF system are investigated systematically in this paper. The coupling and ground springs have both quadratic and cubic non-linearity simultaneously.
Ji, J. +5 more
core +1 more source
Remnant cholesterol and suicide attempts in untreated first-episode major depressive disorder
Frontiers in PsychiatryObjectiveThe objective of this research was to investigate the relationship between remnant cholesterol (RC) levels and suicide attempts (SA) made by Chinese patients with untreated first-episode major depressive disorder (UFE MDD).MethodsThis study ...
Ping Xu +9 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Non-linear strategies in a linear quadratic differential game [PDF]
We study non-linear Markov perfect equilibria in a two agent linear quadratic differential game. In contrast to the literature owing to Tsutsui and Mino (1990), we do not associate endogenous subsets of the state space with candidate solutions.
Colin Rowat
core
Crawlers in viscous environments: Linear vs non-linear rheology
, 2013 We study model self-propelled crawlers which derive their propulsive capabilities from the tangential resistance to motion offered by the environment.
Noselli, Giovanni +14 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Group analysis of kinetic equations in a non-linear thermal transport problem
, 2015 An application of modern group analysis to electron kinetic equations in non-linear thermal transport problem is discussed. The admitted symmetry group is calculated, and the optimal system of one and two-dimensional subalgebras is constructed ...
Meleshko, S. V. +3 more
core +1 more source