Results 121 to 130 of about 14,727,707 (258)

Spatio-Temporal Evolution and Synergistic Development of Urban Road Infrastructure and Urbanization: Evidence from 101 Chinese Cities

Systems
Balancing the development of urban road infrastructure (URI) with the pace of urbanization is crucial to supporting high-quality urban growth. This study constructed a comprehensive evaluation framework of URI and urbanization using data from 101 Chinese
Mengzhen Ding, Jun Cai, Jiaqi Xu, Qiyao Yang, Feiyang Chen, Yishuang Wu   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Association between hyperuricemia and kidney stones in Southern China: a multicentre cross-sectional study

Frontiers in Endocrinology
BackgroundHyperuricemia has been identified as a significant independent risk factor for kidney stones. However, a paucity of research has been conducted on the correlation between hyperuricemia in the general population and the prevalence of kidney ...
Yuwen Zhong, Rongxin He, Ganglin Kang, Zhongfang Zhou, Kaimin Xiao, Li Li   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Generalization of the Achenbach-Chao model for waves in non-linear hereditary media

, 1996
An analogue of the Achenbach-Chao model for the case of wave propagation in non-linear hereditary elastic media is considered.
Itskovits, MA,
core  

Maternal mineral nutrition during early pregnancy and neonatal growth: findings from a China birth cohort study

Frontiers in Nutrition
ObjectivesNeonatal growth holds great significance for lifelong health, but the effects of maternal mineral nutrition during pregnancy on neonatal growth remain unclear.
Doudou Zhao, Doudou Zhao, Yanfang Song, Liang Li, Nan Li, Yu Zhang, Yiting Li, Kangxin Wang, Yang Mi, Lei Shang, Pengfei Qu, Pengfei Qu   +11 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Fourier Analysis and Synthesis for a Mildly Non-Linear Quantizer

, 1999
This Unclassified Report is a compilation, extended with certain new results, of those parts of NLR 6918/96 (A.J.E.M. Janssen), NLR 6923/96 (M.T. Looijer), NLTN 423/96 (A.J.E.M. Janssen), NLR 7006 (R. de Vries, A.J.E.M. Janssen) and NLR 7043/98 (A.J.E.M.
Non-linear Quantizer, A.J.E.M. Janssen
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source