Results 91 to 100 of about 360,599 (282)
, 2007 A two-level system that is coupled to a high-finesse cavity in the Purcell regime exhibits a giant optical non-linearity due to the saturation of the two-level system at very low intensities, of the order of one photon per lifetime. We perform a detailed
Alexia Auffèves-Garnier +8 more
core +3 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Preface: physics of disorder, non-equilibrium and non-linearity
National Science Open, 2023 Jin Yuliang, Chen Ke, Sun Yong-Hao
doaj +1 more source
Understanding and Ameliorating Non-Linear Phase and Amplitude Responses in AMCW Lidar
Remote Sensing, 2011 Amplitude modulated continuous wave (AMCW) lidar systems commonly suffer from non-linear phase and amplitude responses due to a number of known factors such as aliasing and multipath inteference. In order to produce useful range and intensity information
John P. Godbaz +2 more
doaj +1 more source
Higher order non-linear effects in a Josephson parametric amplifier
, 2015 Non-linearity of the current-phase relationship of a Josephson junction is the key resource for a Josephson parametric amplifier (JPA), the only device in which the quantum limit has so far been achieved at microwave frequencies.
Fedorov, Arkady, Kochetov, Bogdan A.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Editorial: Non-Linearity in Life Cycle Assessment
Frontiers in Sustainability, 2022 Dingsheng Li +2 more
doaj +1 more source
Reaction-diffusion systems with 1-homogeneous non-linearity
Electronic Journal of Differential Equations, 2002 We describe the dynamics of a system of two reaction-diffusion equations with 1-homogeneous non-linearity. We show that either an order-preserving property holds and can be used in order to determine the limiting behaviour in some (invariant) sets or the
Matthias Bueger
doaj