Results 91 to 100 of about 367,297 (292)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Anderson Localization, Non-linearity and Stable Genetic Diversity

, 2006
In many models of genotypic evolution, the vector of genotype populations satisfies a system of linear ordinary differential equations. This system of equations models a competition between differential replication rates (fitness) and mutation.
Charles L. Epstein, D. J. Thouless, D. R. Nelson, E. Baake, H. Wagner, J. F. Crow, J. Hermisson, J. McCaskill, L. A. Pastur, M. E. Taylor, M. Eigen, M. Eigen, M. Eigen, M. Eigen, M. Reed, P. B. Rainey, P. W. Anderson, R. Abou-Chacra, R. Carmona, S. S. Chow   +19 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Preface: physics of disorder, non-equilibrium and non-linearity

National Science Open, 2023
Jin Yuliang, Chen Ke, Sun Yong-Hao
doaj   +1 more source

VIBRATION SUPRESSION OF NON-LINEAR SYSTEM VIA NON-LINEAR ABSORBER

Menoufia Journal of Electronic Engineering Research, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Amer, Y. A., El-Sayed, A. T.
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Editorial: Non-Linearity in Life Cycle Assessment

Frontiers in Sustainability, 2022
Dingsheng Li, Michael P. Tsang, Harn Wei Kua   +2 more
doaj   +1 more source

Reaction-diffusion systems with 1-homogeneous non-linearity

Electronic Journal of Differential Equations, 2002
We describe the dynamics of a system of two reaction-diffusion equations with 1-homogeneous non-linearity. We show that either an order-preserving property holds and can be used in order to determine the limiting behaviour in some (invariant) sets or the
Matthias Bueger
doaj  

Non-linear clock for digitizers [PDF]

Nuclear Instruments and Methods, 1978
Abstract A digital method for generating pulses whose frequency varies with time is described. The variation of frequency obtained is stable, controllable and predictable. These pulses used in conjunction with time or charge digitizers allow measurements over a wider range of time or energy in a digitizer having memory or buffer store of a limited ...
openaire   +2 more sources