Results 61 to 70 of about 367,297 (292)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Reduced Order Probabilistic Emulator of RAM‐SCB: Toward Non‐Linearity With Autoencoders
Space WeatherAn accurate understanding of the Earth's ring current dynamics is integral to predicting the impacts of geomagnetic storms. We use physics‐based models to simulate the ring current such as the Ring‐current Atmosphere interactions Model with Self ...
Q. Al Shidi, P. M. Mehta
doaj +1 more source
Milky Way dust extinction measured with QSOs [PDF]
, 2014 We investigate reddening by Milky Way dust in the low-extinction regime of $E_{B-V}
Wolf, Christian
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Influence of Non-Linearity on Selected Cryptographic Criteria of 8x8 S-Boxes
Acta Informatica Pragensia, 2017 The article defines standard criteria used to characterize the cryptographic quality of the S box: regularity, non linearity, autocorrelation, avalanche and immunity against differential cryptanalysis.
Petr Tesař
doaj +1 more source
Dependencies in political studies (non-linearity and typical methodological errors) [PDF]
SHS Web of Conferences, 2019 The article raises the question of studying the statistical dependencies in a sociological research. Most sociologists, if they study cause and effect relations, offer interpretations of only linear relations and linear models based on their data ...
Basimov Mikhail
doaj +1 more source
Non-linearity of insulin kinetics [PDF]
Diabetologia, 1986 Existe-t-il une proportionnalite entre les concentrations plasmatiques et les taux de disparition plasmatique de l'insuline?
B, Thorsteinsson +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source