Results 111 to 120 of about 88,677 (293)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The Einstein–Podolsky–Rosen Steering and Its Certification

open access: yesEntropy, 2019
The Einstein–Podolsky–Rosen (EPR) steering is a subtle intermediate correlation between entanglement and Bell nonlocality. It not only theoretically completes the whole picture of non-local effects but also practically inspires novel quantum ...
Yi-Zheng Zhen   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The Quantum Mechanism of Tao Calligraphy: A New Paradigm of Quantum Healing

open access: yesReports in Advances of Physical Sciences
Tao Calligraphy, developed by Dr. and Master Zhi Gang Sha, is a unique healing modality based on yi bi zi — a one-stroke Chinese calligraphy technique. Clinical studies and case reports demonstrate its therapeutic benefits across physical, emotional and ...
Zhi Gang Sha, Rulin Xiu
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Pauli-based fermionic teleportation with free massive particles by electron-exchange collisions

open access: yesNew Journal of Physics, 2019
Fundamental non-locality in quantum mechanical scattering processes is investigated by means of Fermionic teleportation. Our scenario employs free massive particles, electrons and atoms, within a twofold electron-exchange collision approach whereby, in ...
Bernd Lohmann, Karl Blum
doaj   +1 more source

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