Results 121 to 130 of about 88,677 (293)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

The Evolution of Fractional Calculus

open access: yesChaos Theory and Applications, 2022
Fractional Calculus started in 1695 with Leibniz discussing the meaning of $D^ny$ for $n = 1/2$. Many mathematicians  developed the theoretical concepts, but the area remained somewhat unknown from applied sciences.
José A. Tenreiro Machado
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Fractional Scalar Field Cosmology

open access: yesFractal and Fractional
Considering the Friedmann–Lemaître–Robertson–Walker (FLRW) metric and the Einstein scalar field system as an underlying gravitational model to construct fractional cosmological models has interesting implications in both classical and quantum regimes ...
Seyed Meraj Mousavi Rasouli   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Locality constrained dictionary learning for non‐linear dimensionality reduction and classification

open access: yesIET Computer Vision, 2017
In view of the incremental dimensionality reduction problem of existing non‐linear dimensionality reduction methods, a novel algorithm, based on locality constrained dictionary learning (LCDL), is proposed in this study.
Lina Liu, Shiwei Ma, Ling Rui, Jian Lu
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Programming Telepathy: Implementing Quantum Non-Locality Games

open access: yes, 2008
Quantum pseudo-telepathy is an intriguing phenomenon which results from the application of quantum information theory to communication complexity. To demonstrate this phenomenon researchers in the field of quantum communication complexity devised a ...
Hehner, Eric C. R., Tafliovich, Anya
core   +4 more sources

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