Results 71 to 80 of about 70,789 (216)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
What is the most efficient way to generate random numbers device-independently using a photon pair source based on spontaneous parametric down conversion?
V Caprara Vivoli +8 more
doaj +1 more source
Entanglement and Non-Locality in Quantum Protocols with Identical Particles. [PDF]
Benatti F, Floreanini R, Marzolino U.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
A system’s wave function is uniquely determined by its underlying physical state
We address the question of whether the quantum-mechanical wave function Ψ of a system is uniquely determined by any complete description Λ of the system’s physical state.
Roger Colbeck, Renato Renner
doaj +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Bell’s stated assumptions in deriving his inequality were sufficient conditions. It is shown that a far simpler condition exists for derivation of the inequality: the mere existence of finite data sets regardless of their statistical or deterministic ...
Sica Louis
doaj +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
При решении задач математического моделирования часто приходится обращаться к теории интегрально-дифференциального исчисления. С ее помощью можно описывать динамические процессы самой разной природы.
Твёрдый, Д.А. +1 more
doaj +1 more source

