Results 101 to 110 of about 79,198 (289)

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

The landscape of inherited and de novo copy number variants in a plasmodium falciparum genetic cross

BMC Genomics, 2011
Background Copy number is a major source of genome variation with important evolutionary implications. Consequently, it is essential to determine copy number variant (CNV) behavior, distributions and frequencies across genomes to understand their origins
Tan Asako, Patel Jigar J, Gonzales Joseph M, Samarakoon Upeka, Checkley Lisa, Ferdig Michael T   +5 more
doaj   +1 more source

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source

Morpho -genetic variability in F 2 progeny cowpea genotypes tolerant to bruchid (Callosobruchus maculatus) [PDF]

Journal of Agricultural Sciences (Belgrade), 2019
Callosobruchus maculatus Fab. is a major threat to cowpea production reducing the quality, quantity and market value of cowpea grains. A cheap and easy identification method would be a valuable tool in identifying and breeding resistant genotypes in the ...
Amusa Oluwafemi D., Ogunkanmi Adebayo L., Adetumbi Johnson A., Akinyosoye Solomon T., Ogundipe Oluwatoyin T.   +4 more
doaj  

3D Molecular Cytology of Hop (Humulus lupulus) Meiotic Chromosomes Reveals Non-disomic Pairing and Segregation, Aneuploidy, and Genomic Structural Variation

Frontiers in Plant Science, 2018
Hop (Humulus lupulus L.) is an important crop worldwide, known as the main flavoring ingredient in beer. The diversifying brewing industry demands variation in flavors, superior process properties, and sustainable agronomics, which are the focus of ...
Katherine A. Easterling, Katherine A. Easterling, Nicholi J. Pitra, Rachel J. Jones, Lauren G. Lopes, Jenna R. Aquino, Dong Zhang, Paul D. Matthews, Hank W. Bass   +8 more
doaj   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Unravelling the genetics of non-random fertilization associated with gametic incompatibility

Scientific Reports, 2022
In the dairy industry, mate allocation is dependent on the producer’s breeding goals and the parents’ breeding values. The probability of pregnancy differs among sire-dam combinations, and the compatibility of a pair may vary due to the combination of ...
Audrey A. A. Martin, Samir Id-Lahoucine, Pablo A. S. Fonseca, Christina M. Rochus, Lucas M. Alcantara, Dan Tulpan, Stephen J. LeBlanc, Filippo Miglior, Joaquim Casellas, Angela Cánovas, Christine F. Baes, Flavio S. Schenkel   +11 more
doaj   +1 more source

Electro‐clinical features of Mowat–Wilson syndrome: A retrospective study of 31 children in mainland China

Epileptic Disorders, EarlyView.
Abstract Objective To summarize the electro‐clinical and genetic characteristics of children with Mowat–Wilson syndrome (MWS). Methods This study is a hospital‐based case series analyzing clinical data from 31 pediatric patients with MWS and epilepsy treated at Peking University First Hospital between June 2020 and December 2024.
Yi Ju, Tao‐yun Ji
wiley   +1 more source

Hook Students with the Super Bowl and a Protein Modeling Activity to Teach Genetic Concepts

Journal of Microbiology & Biology Education, 2014
Teaching Biology concepts such as molecular genetics and inheritance patterns to students in K-12 and college is challenging. The created Super Bowl Activity uses kinesthetic and visual models and a "hook" to engage students in the material.
Ann H. Williams, Megan Malone, Heather D. Masonjones, Rebecca J. Waggett   +3 more
doaj   +1 more source

Chromosome drives via CRISPR-Cas9 in yeast

Nature Communications, 2020
Self-propagating drive systems are capable of causing non-Mendelian inheritance. Here, we report a drive system in yeast referred to as a chromosome drive that eliminates the target chromosome via CRISPR-Cas9, enabling the transmission of the desired ...
Hui Xu, Mingzhe Han, Shiyi Zhou, Bing-Zhi Li, Yi Wu, Ying-Jin Yuan   +5 more
doaj   +1 more source