Results 11 to 20 of about 109,513 (348)
Evidence for Non‐Mendelian Inheritance in Spastic Paraplegia 7 [PDF]
Movement Disorders, 2021 Although the typical inheritance of spastic paraplegia 7 is recessive, several reports have suggested that SPG7 variants may also cause autosomal dominant hereditary spastic paraplegia (HSP).
Mehrdad A. Estiar +19 more
semanticscholar +6 more sources
RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse [PDF]
Nature, 2006 Paramutation is a heritable epigenetic modification induced in plants by cross-talk between allelic loci. Here we report a similar modification of the mouse Kit gene in the progeny of heterozygotes with the null mutant Kit(tm1Alf) (a lacZ insertion). In spite of a homozygous wild-type genotype, their offspring maintain, to a variable extent, the white ...
Minoo Rassoulzadegan +5 more
semanticscholar +10 more sources
Clarifying Mendelian vs non-Mendelian inheritance. [PDF]
GeneticsGregor Mendel developed the principles of segregation and independent assortment in the mid-1800s based on his detailed analysis of several traits in pea plants.
Strome S +4 more
europepmc +7 more sources
Mechanisms of non-Mendelian inheritance in genetic disease [PDF]
Human Molecular Genetics, 2004 Single gene disorders with Mendelian inheritance patterns have contributed greatly to the identification of genes and pathways implicated in genetic disease. In these cases, molecular analysis predicts disease status relatively directly.
Veronica van Heyningen
semanticscholar +5 more sources
Sexual Dimorphism in Non-Mendelian Inheritance [PDF]
Pediatric Research, 2008 There is accumulating evidence for nongenetic transgenerational inheritance with conspicuous marked sexual dimorphism for both the modes of transmission and the effects. Given the critical spatiotemporal windows, the role of the sex chromosomes, the regulatory pathways underlying sexual differentiation during gonad and brain development, and other ...
Alexandre Vigé +2 more
semanticscholar +5 more sources
Asymmetric Inheritance: The Diversity and Evolution of Non-Mendelian Reproductive Strategies [PDF]
Annual Review of Ecology, Evolution, and Systematics, 2022 The ability to reproduce is the key trait that distinguishes living organisms from inorganic matter, and the strategies used to achieve successful reproduction are almost as diverse as the organisms themselves.
Laura Ross +3 more
semanticscholar +5 more sources
Colorectal Cancer Risk between Mendelian and Non-Mendelian Inheritance. [PDF]
Clin Colon Rectal Surg, 2023 Hereditary colorectal cancer has been an area of focus for research and public health practitioners due to our ability to quantify risk and then act based on such results by enrolling patients in surveillance programs.
Hibler EA, Szymaniak B, Abbass MA.
europepmc +6 more sources
Mitochondrial heteroplasmy and the evolution of insecticide resistance: Non-Mendelian inheritance in action [PDF]
Proceedings of the National Academy of Sciences, 2008 Genes encoded by mitochondrial DNA (mtDNA) exist in large numbers per cell but can be selected very rapidly as a result of unequal partitioning of mtDNA between germ cells during embryogenesis. However, empirical studies of this “bottlenecking” effect are rare because of the apparent scarcity of heteroplasmic individuals possessing more ...
Thomas Van Leeuwen +6 more
semanticscholar +6 more sources
Non-Mendelian Inheritance of DNA-Induced Inositol Independence in Neurospora [PDF]
Proceedings of the National Academy of Sciences, 1973 Inositol-independent (inos(+)) revertants of Neurospora induced in inositol-requiring mutants by treatment with wild-type DNA in previous studies were found to be stable and to grow well in the absence of inositol.
N.C. Mishra, E. L. Tatum
semanticscholar +4 more sources
The nucleoside diphosphate kinase gene Nme3 acts as quantitative trait locus promoting non-Mendelian inheritance. [PDF]
PLoS Genetics, 2012 The t-haplotype, a variant form of the t-complex region on mouse chromosome 17, acts as selfish genetic element and is transmitted at high frequencies (> 95%) from heterozygous (t/+) males to their offspring.
Hermann Bauer +5 more
doaj +4 more sources