A male-transmitted B chromosome undergoes strong meiotic drag in females of the jewel wasp Nasonia vitripennis. [PDF]
Ferree PM +4 more
europepmc +1 more source
Tianma granule (TMG) inhibits colorectal cancer progression by modulating miR‐29a‐5p/P53 signaling in the tumor microenvironment, reducing stromal senescence and countering pro‐tumorigenic effects. ABSTRACT Chemotherapy‐induced senescence‐associated tumor microenvironment (S‐TME) facilitates colorectal cancer (CRC) progression.
Xiaojuan Tang +5 more
wiley +1 more source
Deviation From Genetically Predicted BMI and All‐Cause Mortality: A Cohort Study in the UK Biobank
ABSTRACT Objective The relation between genetically predicted BMI (gBMI) and actual BMI may have health effects. This study examines the relationship between deviations from gBMI and all‐cause mortality in 208,146 UK Biobank participants. Methods We derived gBMI from polygenic risk scores, with deviations calculated as the difference between observed ...
Nuno R. Zilhao +4 more
wiley +1 more source
From autoimmune inflammation to malignancy: causal genetic evidence for the RA-squamous cell lung cancer axis. [PDF]
Li J +5 more
europepmc +1 more source
Fibroblast‐specific palladin drives kidney fibrosis via MRTF–SRF signaling
Abstract Fibrosis is a common end‐stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin‐related transcription factor (MRTF)–serum response factor (SRF) signaling drives the expression of fibrosis‐related molecules through actin cytoskeleton dynamics in renal fibroblasts.
Naoki Yamamoto +27 more
wiley +1 more source
HSP90 as an evolutionary capacitor drives adaptive eye size reduction via atonal. [PDF]
Sayed R +8 more
europepmc +1 more source
Functional synergy and genomic linkage of glyphosate resistance traits in Canada fleabane
Stacking target‐site and non‐target‐site glyphosate resistance mechanisms in Conyza canadensis results in strong synergistic effects. This study quantifies gene × gene interactions and maps linked resistance loci, advancing our understanding of herbicide resistance genetics and informing management strategies.
Eric R Page +4 more
wiley +1 more source
The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk: a two-step mediation Mendelian randomisation study. [PDF]
Ouyang J, Zhang R, Lv W, Lu Y.
europepmc +1 more source

