Results 221 to 230 of about 79,198 (289)

Targeting Senescence: Tianma Granule Inhibits Colorectal Cancer Progression by Modulating miR‐29a‐5p/P53 Signaling in the Tumor Microenvironment

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 2, 29 January 2026.
Tianma granule (TMG) inhibits colorectal cancer progression by modulating miR‐29a‐5p/P53 signaling in the tumor microenvironment, reducing stromal senescence and countering pro‐tumorigenic effects. ABSTRACT Chemotherapy‐induced senescence‐associated tumor microenvironment (S‐TME) facilitates colorectal cancer (CRC) progression.
Xiaojuan Tang   +5 more
wiley   +1 more source

Deviation From Genetically Predicted BMI and All‐Cause Mortality: A Cohort Study in the UK Biobank

open access: yesObesity, Volume 34, Issue 1, Page 228-236, January 2026.
ABSTRACT Objective The relation between genetically predicted BMI (gBMI) and actual BMI may have health effects. This study examines the relationship between deviations from gBMI and all‐cause mortality in 208,146 UK Biobank participants. Methods We derived gBMI from polygenic risk scores, with deviations calculated as the difference between observed ...
Nuno R. Zilhao   +4 more
wiley   +1 more source

Fibroblast‐specific palladin drives kidney fibrosis via MRTF–SRF signaling

open access: yesThe Journal of Pathology, Volume 268, Issue 1, Page 40-53, January 2026.
Abstract Fibrosis is a common end‐stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin‐related transcription factor (MRTF)–serum response factor (SRF) signaling drives the expression of fibrosis‐related molecules through actin cytoskeleton dynamics in renal fibroblasts.
Naoki Yamamoto   +27 more
wiley   +1 more source

HSP90 as an evolutionary capacitor drives adaptive eye size reduction via atonal. [PDF]

open access: yesNat Commun
Sayed R   +8 more
europepmc   +1 more source

Functional synergy and genomic linkage of glyphosate resistance traits in Canada fleabane

open access: yesPest Management Science, Volume 82, Issue 1, Page 305-318, January 2026.
Stacking target‐site and non‐target‐site glyphosate resistance mechanisms in Conyza canadensis results in strong synergistic effects. This study quantifies gene × gene interactions and maps linked resistance loci, advancing our understanding of herbicide resistance genetics and informing management strategies.
Eric R Page   +4 more
wiley   +1 more source

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