Results 111 to 120 of about 29,285 (164)
Some of the next articles are maybe not open access.
Effects of Non-Narcotic Analgesics on the Liver
Drugs, 1986Serious hepatotoxicity is uncommon with the proper therapeutic use of non-narcotic analgesics but experience with new non-steroidal anti-inflammatory drugs (NSAIDs) is limited. Drugs such as ibufenac, fenclofenac and benoxaprofen were withdrawn from the market because of hepatotoxicity, and liver damage has been reported on occasion with virtually all ...
openaire +2 more sources
Effects of Non-Narcotic Analgesics on the Kidney
Drugs, 1986Non-narcotic analgesics have acute and chronic effects on the kidney. Until quite recently chronic effects have received much more attention than acute effects. Renal papillary necrosis attributed to prolonged intake of analgesic compounds was first described from Switzerland in the 1950s, and subsequently in many countries including Scandinavia ...
openaire +2 more sources
Flunixin meglumine: a non-narcotic analgesic.
The Journal of Pharmacology and Experimental Therapeutics, 1977The N-methyl-d-glucamine salt of flunixin (flunixin meglumine) is a potent non-narcotic analgesic agent after parenteral administration in mice, rats and monkeys. It is significantly more potent than pentazocine, meperidine and codeine in the rat yeast paw test after subcutaneous administration in saline.
V B, Ciofalo +3 more
openaire +2 more sources
Non-narcotic Modalities for the Management of Acute Pain
Critical Care Clinics, 1989The possible options for the management of acute pain are quite numerous and continue to expand as our understanding of the mechanisms of pain becomes increasing sophisticated. Many of the options discussed have been available for years, and their present underutilization may be a reflection of the lack of emphasis on the importance of management of ...
openaire +2 more sources
Gastrointestinal Intolerance and Bleeding with Non-Narcotic Analgesics
Drugs, 1986Aspirin and paracetamol (acetaminophen) are the most commonly used minor analgesics, but their effects on the gastrointestinal tract differ widely. The effects of other nonsteroidal anti-inflammatory drugs (NSAIDs), including phenylbutazone, are intermediate.
openaire +2 more sources
Non-Narcotics and Co-Analgesics
1984Aspirin and other non-steroidal antiinflammatory drugs (NSAIDs) and paracetamol are the most important of the non-narcotic analgesics. As simple analgesics they have equal potency but paracetamol is generally better tolerated, particularly with regard to gastrointestinal side-effects1.
openaire +1 more source
Floctafenine, a new non-narcotic analgesic.
Archives internationales de pharmacodynamie et de therapie, 1975Floctafenine has been studied in comparison with acetyl-salicylic acid, indomethacin and d-propoxyphene in a series of tests for analgesic and anti-inflammatory activity. It is very active in the acetic acid-induced writhing test and on the inflamed paw in the Randall and Selitto test. Furthermore, like acetylsalicylic acid and indomethacin, but unlike
M, Peterfalvi +4 more
openaire +1 more source
Non-narcotic robotic radical prostatectomy
Journal of the American College of Surgeons, 2004Abstract Introduction: Open radical prostatectomy has traditionally been associated with significant bleeding requiring blood transfusion. The patients often have pain requiring nacotics. Recovery is usually over 4 weeks. Using the davinci robot and the on-q pain management system we are now able to perform prostatectomy without significant blood ...
openaire +1 more source
The toxicology of non-narcotic analgesics.
Agents and actions. Supplements, 1986The fact that aminopyrine is readily nitrosated and that the nitrosation product, dimethylnitrosamine, is potentially carcinogenic has led to the drug being withdrawn from therapeutic use. In the case of the other analgesics, nitrosation is not of any importance, neither in toxicological nor quantitative terms.
openaire +1 more source
[Mode of action of non-narcotic analgesics].
Revue du rhumatisme et des maladies osteo-articulaires, 1992According to Lim's experiments, non-narcotic analgesics are usually considered as "peripherally" acting drugs. Conversely, most of these compounds were shown to easily cross the blood-brain barrier, and hence partly produce their effects by a central mechanism. The relative contribution of each site of action may vary from one drug to another.
B, Bannwarth +5 more
openaire +1 more source