Results 111 to 120 of about 57,158 (293)

Aberrant Wnt/β-Catenin Signaling Pathway in Testis of Azoospermic Men​ [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: The Importance and key role of Wnt/β-catenin signaling pathway in spermatogenesis is known. Abnormalities of this pathway in Sertoli and germ cells leads to infertility.
Marefat Ghaffari Novin, Reza Mirfakhraie, Hamid Nazarian   +2 more
doaj   +1 more source

Biallelic mutations in RNA-binding protein ADAD2 cause spermiogenic failure and non-obstructive azoospermia in humans

Human Reproduction Open, 2023
STUDY QUESTION What are some pathogenic mutations for non-obstructive azoospermia (NOA) and their effects on spermatogenesis? SUMMARY ANSWER Biallelic missense and frameshift mutations in ADAD2 disrupt the differentiation of round spermatids to ...
Baolu Shi, Wasim Shah, Li Liu, Chenjia Gong, Jianteng Zhou, Tanveer Abbas, Hui Ma, Huan Zhang, Menglei Yang, Yuanwei Zhang, Nadeem Ullah, Zubair Mahammad, M. Khan, G. Murtaza, Asim Ali, R. Khan, J. Sha, Yan Yuan, Qinghua Shi   +18 more
semanticscholar   +1 more source

Testicular sperm extraction using microdissection for non‐obstructive azoospermia

Reproductive Medicine and Biology, 2002
Background : Men presenting with non‐obstructive azoospermia (NOA) caused by germinal failure can now be treated in some cases using testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI). However, TESE is a blind procedure that does not identify the focal sperm‐producing areas until excision of the ...
Hatsuki, Hibi, Tomohiro, Taki, Yoshiaki, Yamada, Nobuaki, Honda, Hidetoshi, Fukatsu, Masanori, Yamamoto, Yoshimasa, Asada   +6 more
openaire   +2 more sources

Seminal Plasma Exosomal miRNA Profiling Reveals hsa‐miR‐7‐5p as a Key Regulator of Sperm Motility in Asthenozoospermia

Andrology, EarlyView.
ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu, Meng‐Li Cui, Wen‐Jing Yuan, Jia‐Ning Zhang, Shuo Zhang, Xi‐Qiao Yao, Ruo‐Qing Li, Jin‐Feng Li, En‐Zhong Li   +8 more
wiley   +1 more source

Association of CYP1A1*2A Polymorphism with Idiopathic Non-Obstructive Azoospermia in A South Indian Cohort [PDF]

International Journal of Fertility and Sterility, 2017
Background: Infertility is the inability of a couple to conceive after one and a half years of unprotected sex. Male infertility, which accounts for almost half of infertility cases, is considered as a major problem all over the world.
Shalaka S Ramgir, Nishu Sekar, Divya Jindam., Abilash V.G.   +3 more
doaj   +1 more source

The effect of discordance between embryologist and pathologist on sperm retrieval rates in patients with non-obstructive azoospermia undergoing mTESE [PDF]

, 2023
Mehmet Şahin, Osman Can, Emin Taha Keskin, Yiğit Can Filtekin, Halil Lütfi Canat   +4 more
openalex   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Male infertility [PDF]

, 2012
published_or_final_versio
Ho, PC, Lee, VCY, Ng, EHY
core  

The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia [PDF]

, 2011
The aim of this study was to verify the role of antegrade scrotal sclerotherapy for the treatment of varicoceles in infertile men with severe oligo-astheno-teratozoospermia (OAT).
Dohle, G.R. (Gert), Ghanem, M.A.I. (Mazen), Ghanem, M.A.I. (Mazen), Safan, M.A. (Manal A.)   +3 more
core   +1 more source

Intracytoplasmic sperm injection for treatment of non-obstructive azoospermia

Gynecological Endocrinology, 1997
Four cases from a tertiary care teaching medical center were studied to assess the potential of sperm extraction, fertilization and the establishment of pregnancy in couples with non-obstructive azoospermia. Four couples with non-obstructive azoospermia underwent intracytoplasmic sperm injection after testicular sperm extraction.
M I, Abuzeid, M A, Sasy, H H, Salem
openaire   +2 more sources