Results 141 to 150 of about 54,369 (287)

Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1 [PDF]

, 2013
Gonadal failure, along with early pregnancy loss and perinatal death, may be an important filter that limits the propagation of harmful mutations in the human population.
Amorim, Antonio, Aston, Kenneth I., Barros, Alberto, Carracedo, A., Carrell, D.T., Carvalho, Filipa, Conrad, D.F., Dai, Juncheng, Downie, Jonathan, Fernandes, Susana, Gonçalves, João, Guo, Xuejiang, Hu, Z., Huang, N., Hurles, M.E., Lopes, Alexandra, Matthiesen, Rune, Moskovtsev, S., Noordam, Michiel J., Ober, C., Paduch, D.A., Quintela, Ines, Ramu, Avinash, Schiffman, J.D., Schlegel, P.N., Seabra, Catarina, Shah, Jiahao, Sousa, M., Thompson, Emma E, Wilfert, Amy B.   +29 more
core   +3 more sources

Innovative all‐in‐one exome sequencing strategy for diagnostic genetic testing in male infertility: Validation and 10‐month experience

Andrology, Volume 13, Issue 5, Page 1078-1092, July 2025.
Abstract Background Current guidelines indicate that patients with extreme oligozoospermia or azoospermia should be tested for chromosomal imbalances, azoospermia factor (AZF) deletions and/or CFTR variants. For other sperm abnormalities, no genetic diagnostics are recommended.
Manon S. Oud, Nicole de Leeuw, Dominique F. C. M. Smeets, Liliana Ramos, Godfried W. van der Heijden, Raoul G. J. Timmermans, Maartje van de Vorst, Tom Hofste, Marlies J. E. Kempers, Marijn F. Stokman, Kathleen W. M. D'Hauwers, Brigitte H. W. Faas, Dineke Westra   +12 more
wiley   +1 more source

Male infertility [PDF]

, 2012
published_or_final_versio
Ho, PC, Lee, VCY, Ng, EHY
core  

Ultrasonographic Appearance of the Deferent Ducts in Dogs without Genitourinary Disease

Veterinary Radiology &Ultrasound, Volume 66, Issue 4, July 2025.
ABSTRACT In veterinary medicine, deferent ducts are described as being visible on ultrasound only when pathologically enlarged. Abnormal ultrasonographic enlargement of the deferent ducts has primarily been described secondary to infectious and neoplastic diseases; however, no studies have evaluated the normal ultrasonographic features of these ...
Anna Palomares, Yvonne Espada, Mauricio Tobón Restrepo, Sonia González‐Rellán, Rosa Novellas   +4 more
wiley   +1 more source

Seminal bacterial composition in patients with obstructive and non‑obstructive azoospermia

Experimental and Therapeutic Medicine, 2018
A number of culture-dependent and -independent studies have reported that the number and significance of bacterial species in semen may have been underestimated. The aim of the present study was to profile the seminal microbiome in patients with obstructive or non-obstructive azoospermia.
Tao Luo, Houyang Chen, Wang Gongxian, Tingtao Chen   +3 more
openaire   +3 more sources

HELQ Maintains Genome Stability of Primordial Germ Cells by Inhibiting LINE‐1 Expression

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
HELQ interacts with the histone demethylase KDM4B to maintain the level of H3K9me3 modification in the LINE‐1 region, thus inhibiting its expression and preserving genome stability. HELQ deficiency leads to elevated levels of KDM4B and reduces H3K9me3 modification, which increases LINE‐1 expression and subsequently genome instability in primordial germ
Lili Cao, Jiayi Ren, Zhaojie Kong, Mengchun Hu, Yaxuan Zhang, Zi‐Jiang Chen, Yingying Qin, Yajuan Yang, Shidou Zhao   +8 more
wiley   +1 more source

Surgical sperm retrieval: Techniques and their indications

Indian Journal of Urology, 2011
Men with azoospermia can father a child through intra-cytoplasmic sperm injection if sperm can be retrieved from their epididymis or testis. Several percutaneous and open surgical procedures have been described to retrieve sperm.
Rupin Shah
doaj   +1 more source

Chromosomal disorders and male infertility [PDF]

, 2015
Male factor infertility is considered a complex disorder with a largely unknown etiology that affects about 7% of men. In general, genetic abnormalities account for 15%-30% of condition and Y chromosome microdeletions are also frequent.
Alves, C., Ambrósio, P., Brito, F., Caetano, I., Correia, H., Geraldes, M.C., Gonçalves, J., Marques, B., Pedro, S., Serafim, S., Silva, M., Simão, L.   +11 more
core  

Association of FSH Level with Spermatogenic Histology Based on Johnson Criteria in Azoospermic Patients [PDF]

, 2017
The aims of this study is to know the association FSH level with spermatogenic histology on testical biopsy and to evaluate the use of FSH level as predictor of the succes of testical biopsy on azoospermic patient using Johnson criteria.  This is a ...
Birowo, P. (Ponco), Jelita, N. K. (Namira), Rasyid, N. (Nur), Sari, P. (Pudji)   +3 more
core  

The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia [PDF]

, 2011
The aim of this study was to verify the role of antegrade scrotal sclerotherapy for the treatment of varicoceles in infertile men with severe oligo-astheno-teratozoospermia (OAT).
Dohle, G.R. (Gert), Ghanem, M.A.I. (Mazen), Ghanem, M.A.I. (Mazen), Safan, M.A. (Manal A.)   +3 more
core   +1 more source