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Genetic mutations contributing to non-obstructive azoospermia
Best Practice & Research Clinical Endocrinology & Metabolism, 2020Non-obstructive azoospermia is a distinct diagnosis within male infertility in which no sperm is found in the ejaculate as a result of spermatogenesis failure. Because of the increased prevalence of genetic abnormalities in men with non-obstructive azoospermia, male infertility guidelines recommend screening for karyotype abnormalities and Y chromosome
Vanessa N, Peña +2 more
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Sperm retrieval techniques in patients with non-obstructive azoospermia
Urologiia, 2021Patients with non-obstructive azoospermia (NOA), which accounts for up to 10-15% of all cases of male infertility, until recently could only become parents using donor sperm or through adoption. Modern technical capabilities of sperm extraction in combination with the use of assisted reproductive technologies, make it possible to effectively overcome ...
N D, Akhvlediani +3 more
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Whole Exome Sequencing and In Silico Analysis of Human Sertoli in Patients with Non-Obstructive Azoospermia [PDF]
Non-obstructive azoospermia (NOA) is a serious cause of male infertility. The Sertoli cell responds to androgens and takes on roles supporting spermatogenesis, which may cause infertility.
Hossein Azizi +2 more
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Obstructive and Non-Obstructive Azoospermia
2012Azoospermia is defined as the complete absence of spermatozoa upon examination of the semen [including capillary tube centrifugation (CTC), strictly confirmed by the absence of spermatozoa issued in urine after ejaculation]. The presence of rare spermatozoa (
PASTORE, ANTONIO LUIGI +4 more
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Glucose and lipid profiles in men with non-obstructive azoospermia
2022Abstract The impact of a low testosterone level among men with non-obstructive azoospermia with various testicular histopathological patterns on the regulation of glucose and lipid metabolism is less well known than among the general population.
Rasyid, Nur +4 more
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Analysis of genes implicated in non-obstructive azoospermia
SteroidsNon-obstructive azoospermia (NOA) is the most common cause of male infertility, accounting for approximately 60 % of azoospermia cases. In recent years, gene mutations have emerged as the primary factor under investigation for the etiology of NOA. Therefore, finding the cause and pathogenesis of NOA at the genetic level has become one of the current ...
Junwei, Wang +3 more
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Intracytoplasmic sperm injection in obstructive and non-obstructive azoospermia
Human Reproduction, 1997We compared the results of intracytoplasmic sperm injection (ICSI) in: (i) obstructive versus non-obstructive azoospermia, (ii) obstructive azoospermia using epididymal versus testicular spermatozoa and (iii) acquired versus congenital obstructive azoospermia due to congenital absence of the vas deferens (CAVD). A retrospective analysis was done of 241
R T, Mansour +5 more
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Non-Obstructive Azoospermia and the Impact of MicroTESE.
Irish medical journal, 2016In non-obstructive azoospermia (NOA), no spermatozoa are present in the ejaculate as a result of compromised or absent spermatogenesis. NOA is distinguished from obstructive azoospermia by patient history, clinical examination and hormone profile. As much as 10% of all male infertility has been attributed to NOA1. In contrast to obstructive azoospermia,
Dineen, T, Waterstone, J, Cullen, I
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[Non-obstructive azoospermia and ICSI].
Contraception, fertilite, sexualite (1992), 199850 cases of non obstructive azoospermia required testicular sperm extraction and ICSI. Results are promising but ability to find spermatozoa remains questionable. Further studies are necessary to improve success of the method. Genetic research also need to be developed for better understanding the process.
M, Adjiman +7 more
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Mechanisms of non-obstructive azoospermia caused by TOP6BL variants
ReproductionIn brief Non-obstructive azoospermia (NOA) is a major cause of male infertility, with many cases having unknown origins. This study identifies two TOP6BL variants linked to NOA, revealing their impact on meiotic DNA double-strand break (DSB ...
Chao Wang +5 more
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