Results 251 to 260 of about 57,158 (293)

Transcriptomic analysis of the Non-Obstructive Azoospermia (NOA) to address gene expression regulation in human testis

Systems Biology in Reproductive Medicine, 2023
There is a need to understand the molecular basis of testes under Non-Obstructive Azoospermia (NOA), a state of failed spermatogenesis. There has been a lack of attention to the transcriptome at the level of alternatively spliced mRNAs (iso-mRNAs) and ...
G. Balagannavar, Kavyashree Basavaraju, A. Bajpai, Sravanthi Davuluri, Shruthi Kannan, Vasan S Srini, Darshan S Chandrashekar, N. Chitturi, Kshitish K Acharya   +8 more
semanticscholar   +1 more source

Profiling of circulating extracellular vesicle microRNAs reveals diagnostic potential and pathways in non-obstructive and obstructive azoospermia

Biology of Reproduction
The accurate diagnosis of non-obstructive azoospermia and obstructive azoospermia is crucial for selecting appropriate clinical treatments. This study aimed to investigate the pivotal role of microRNAs in circulating plasma extracellular vesicles in ...
Yujuan Qi, Yalun Wu, Kun Pang, Yijuan Cao, Honglin Li, Yu Qiao, Dejian Yuan, Xiangen Liu, Zhenbei Li, F-F Hu, Wen Yang, Conghui Han, Zuobin Zhu   +12 more
semanticscholar   +1 more source

Systematic molecular analyses for 115 karyotypically normal men with isolated non-obstructive azoospermia.

Human Reproduction
STUDY QUESTION Do copy-number variations (CNVs) in the azoospermia factor (AZF) regions and monogenic mutations play a major role in the development of isolated (non-syndromic) non-obstructive azoospermia (NOA) in Japanese men with a normal 46, XY ...
Yuki Muranishi, Y. Kobori, Y. Katoh-Fukui, Satoshi Tamaoka, Atsushi Hattori, A. Osaka, H. Okada, K. Nakabayashi, Kenichirou Hata, Tomoko Kawai, Hiroko Ogata-Kawata, T. Iwahata, Kazuki Saito, M. Kon, Nobuo Shinohara, M. Fukami   +15 more
semanticscholar   +1 more source

Non-obstructive azoospermia and clinical varicocele: therapeutic options

International Urology and Nephrology, 2013
Ten to fifteen percent of infertile men are azoospermic, and sixty percent of these men have been classified as having non-obstructive azoospermia (NOA). NOA results from testicular failure, and one of the causes of this is the presence of varicocele. Varicocele is observed in 5-10 % of men with NOA.
openaire   +2 more sources

Intracytoplasmic sperm injection in obstructive and non-obstructive azoospermia

Human Reproduction, 1997
We compared the results of intracytoplasmic sperm injection (ICSI) in: (i) obstructive versus non-obstructive azoospermia, (ii) obstructive azoospermia using epididymal versus testicular spermatozoa and (iii) acquired versus congenital obstructive azoospermia due to congenital absence of the vas deferens (CAVD). A retrospective analysis was done of 241
R T, Mansour, A, Kamal, I, Fahmy, N, Tawab, G I, Serour, M A, Aboulghar   +5 more
openaire   +2 more sources

Testicular piRNA Analysis Identified Dysregulated piRNAs in Non-obstructive Azoospermia

Reproductive Sciences, 2023
Male infertility has remained idiopathic in a remarkable proportion of all cases. Gonadal expression of PIWI-interacting RNAs (piRNAs) has been shown to be vital to normal spermatogenesis, as they are expressed in almost all types of testicular germ cells. These molecules and their related Piwi proteins strictly regulate transposable elements' activity
Fahimeh Piryaei, Poonam Mehta, Hossein Mozdarani, Fatemeh Hamzehlooy, Mahmoud Barati, Zeynab Piryaei, Mohammad Ali Sadighi Gilani, Mohsen Alemi, Rajender Singh   +8 more
openaire   +2 more sources

Novel MEIOB pathogenic variants including a homozygous non‐canonical splicing variant, cause meiotic arrest and human non‐obstructive azoospermia

Clinical Genetics, 2023
Non‐obstructive azoospermia (NOA) is the most severe form of human male infertility, and the genetic causes of NOA with meiotic arrest remain largely unclear.
Xiaoyu Zhu, Kaiqin Hu, Huiru Cheng, Huan Wu, Kuokuo Li, Yang Gao, Mingrong Lv, Chuan Xu, Hao Geng, Q. Shen, Yunxia Cao, Xiaojin He, D. Tang, Rui Guo   +13 more
semanticscholar   +1 more source

Analysis of genes implicated in non-obstructive azoospermia

Steroids
Non-obstructive azoospermia (NOA) is the most common cause of male infertility, accounting for approximately 60 % of azoospermia cases. In recent years, gene mutations have emerged as the primary factor under investigation for the etiology of NOA. Therefore, finding the cause and pathogenesis of NOA at the genetic level has become one of the current ...
Junwei, Wang, Shuhui, Wang, Meng, Wang, Jinfei, Yang   +3 more
openaire   +2 more sources

Exosomes of mesenchymal stem cells and PRP restore spermatogenesis in the rat model of non-obstructive azoospermia.

Reproduction
Patients with non-obstructive azoospermia (NOA) are unable to have their children. Therefore, there is an urgent need for additional treatment alternatives for these patients. Recently, novel treatments based on the exosomes derived from mesenchymal stem
A. Sheikholeslami, Faezeh Davoodi, H. Fazaeli, Mohsen Sheykhhasan, N. Kalhor, Leila Naserpour   +5 more
semanticscholar   +1 more source

[Non-obstructive azoospermia and ICSI].

Contraception, fertilite, sexualite (1992), 1998
50 cases of non obstructive azoospermia required testicular sperm extraction and ICSI. Results are promising but ability to find spermatozoa remains questionable. Further studies are necessary to improve success of the method. Genetic research also need to be developed for better understanding the process.
M, Adjiman, F X, Aubriot, A, Glissant, A, Hazout, C, Nathan, A, Stanovici, M, Dumont, P, Cohen-Bacrie   +7 more
openaire   +1 more source