Results 261 to 270 of about 54,369 (287)

Transcriptomic analysis of the Non-Obstructive Azoospermia (NOA) to address gene expression regulation in human testis

Systems Biology in Reproductive Medicine, 2023
There is a need to understand the molecular basis of testes under Non-Obstructive Azoospermia (NOA), a state of failed spermatogenesis. There has been a lack of attention to the transcriptome at the level of alternatively spliced mRNAs (iso-mRNAs) and ...
G. Balagannavar, Kavyashree Basavaraju, A. Bajpai, Sravanthi Davuluri, Shruthi Kannan, Vasan S Srini, Darshan S Chandrashekar, N. Chitturi, Kshitish K Acharya   +8 more
semanticscholar   +1 more source

Genetic mutations contributing to non-obstructive azoospermia

Best Practice & Research Clinical Endocrinology & Metabolism, 2020
Non-obstructive azoospermia is a distinct diagnosis within male infertility in which no sperm is found in the ejaculate as a result of spermatogenesis failure. Because of the increased prevalence of genetic abnormalities in men with non-obstructive azoospermia, male infertility guidelines recommend screening for karyotype abnormalities and Y chromosome
Vanessa N. Peña, Amin S. Herati, Taylor P. Kohn   +2 more
openaire   +3 more sources

Biological therapy for non-obstructive azoospermia

Expert Opinion on Biological Therapy, 2017
Most male patients with non-obstructive azoospermia (NOA) have no therapeutic options outside of assisted reproductive techniques to conceive a biological child. If mature sperm cannot be obtained from the testes, these patients must rely on options of donor sperm or adoption.
Sarah C. Vij, Ashok Agarwal, Edmund Sabanegh   +2 more
openaire   +3 more sources

Intracytoplasmic sperm injection in obstructive and non-obstructive azoospermia [PDF]

Human Reproduction, 1997
We compared the results of intracytoplasmic sperm injection (ICSI) in: (i) obstructive versus non-obstructive azoospermia, (ii) obstructive azoospermia using epididymal versus testicular spermatozoa and (iii) acquired versus congenital obstructive azoospermia due to congenital absence of the vas deferens (CAVD). A retrospective analysis was done of 241
A Kamal, Nevine A. Tawab, I. Fahmy, Mohamed A. Aboulghar, Ragaa T. Mansour, G.I. Serour   +5 more
openaire   +2 more sources

Reproductive and obstetric outcomes in TESE–ICSI cycles: A comparison between obstructive and non‐obstructive azoospermia

Andrology, 2023
Comparison of intracytoplasmic sperm injection cycles with testicular sperm extraction in obstructive azoospermia and non‐obstructive azoospermia are limited, and few studies have addressed obstetric and neonatal outcomes.
Massimo Romano, F. Cirillo, Noemi Ravaioli, E. Morenghi, L. Negri, Bulbul Ozgur, E. Albani, P. Levi-Setti   +7 more
semanticscholar   +1 more source

Financial decision analysis based on “willingness to pay” for surgical sperm retrieval approaches among men with non‐obstructive azoospermia in the United States

Andrology, 2023
To determine the most financially optimal surgical approach for testicular sperm retrieval for men with non‐obstructive azoospermia.
Tracy X. Han, Brittany D. Berk, R. A. Ghayda, John Ernandez, M. Kathrins   +4 more
semanticscholar   +1 more source

Eligibility for the medical therapy among men with non‐obstructive azoospermia—Findings from a multi‐centric cross‐sectional study

Andrology
Existing literature does not provide accurate epidemiological data regarding the true prevalence of men with non‐obstructive azoospermia (NOA) who would be eligible for hormonal optimization therapy, according to specific pre‐treatment criteria.
Edoardo Pozzi, G. Venigalla, A. Raymo, Vishal Ila, A. Achermann, S. Esteves, A. Salonia, Ranjith Ramasamy   +7 more
semanticscholar   +1 more source

Systematic molecular analyses for 115 karyotypically normal men with isolated non-obstructive azoospermia.

Human Reproduction
STUDY QUESTION Do copy-number variations (CNVs) in the azoospermia factor (AZF) regions and monogenic mutations play a major role in the development of isolated (non-syndromic) non-obstructive azoospermia (NOA) in Japanese men with a normal 46, XY ...
Yuki Muranishi, Y. Kobori, Y. Katoh-Fukui, Satoshi Tamaoka, Atsushi Hattori, A. Osaka, H. Okada, K. Nakabayashi, Kenichirou Hata, Tomoko Kawai, Hiroko Ogata-Kawata, T. Iwahata, Kazuki Saito, M. Kon, Nobuo Shinohara, M. Fukami   +15 more
semanticscholar   +1 more source

A homozygous frameshift variant in SYCP2 caused meiotic arrest and non‐obstructive azoospermia

Clinical Genetics, 2023
Genetic causation for the majority of non‐obstructive azoospermia (NOA) remains unclear. Mutations in synaptonemal complex (SC)‐associated genes could cause meiotic arrest and NOA.
Junwei Xu, Yifan Sun, Yuxiang Zhang, Ningjing Ou, Haowei Bai, Jingpeng Zhao, Shuai Xu, Jiaqiang Luo, Sha Han, Peng Li, R. Tian, E. Zhi, Yu-hua Huang, Jing Zhang, Gang Liu, Zheng Li, C. Yao   +16 more
semanticscholar   +1 more source

Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates to idiopathic non-obstructive azoospermia via inhibiting mitochondrial fission and inducing mitochondrial dysfunction

Biology of Reproduction, 2023
Non-obstructive azoospermia affects more than 10% of infertile men with over 70% patients are idiopathic with uncharacterized molecular mechanisms, which is referred as idiopathic non-obstructive azoospermia.
Lei Wei, Zonggang Feng, Qian Dou, Li Tan, Xinghua Zhao, Bin Hao   +5 more
semanticscholar   +1 more source