Results 111 to 120 of about 7,757,311 (314)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

ROBUSTNESS OF NON-PARAMETRIC MEASUREMENT OF EFFICIENCY AND RISK AVERSION [PDF]

This paper examines the performance of a risk-adjusted non-parametric approach to measuring efficiency and risk aversion. Prior work is extended to the case where agent behavior is motivated by expected utility maximization. Results indicate the approach
Settlage, Daniel M., Preckel, Paul V.
core   +1 more source

icenReg: Regression Models for Interval Censored Data in R

Journal of Statistical Software, 2017
The non-parametric maximum likelihood estimator and semi-parametric regression models are fundamental estimators for interval censored data, along with standard fullyparametric regression models.
Clifford Anderson-Bergman
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Parametric and Multiobjective Optimization with Applications in Finance [PDF]

, 2010
In this thesis parametric analysis for conic quadratic optimization problems is studied. In parametric analysis, which is often referred to as parametric optimization or parametric programming, a perturbation parameter is introduced into the ...
Romanko, Oleksandr
core  

Non-parametric (Spearman) correlations between study indicators. [PDF]

Non-parametric (Spearman) correlations between study indicators.
Daniel S. Farrar (13360112), Rachel F. Spitzer (17619214), Zulfiqar A. Bhutta (8902250), Lisa G. Pell (11947503), Shaun K. Morris (9653945), Monica Taljaard (118231), Sarah M. Abu Fadaleh (18065035), Muhammad Karim (3576419), Imran Ahmed (468418), Diego G. Bassani (7233536), Zachary Tanner (17619208), Shariq Paracha (17619211), Sajid B. Soofi (9081835), Masood Ali Khan (18065032), Sher Hafiz Khan (17619205), Yasin Muhammad (17686093), Falak Madhani (7430240)   +16 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Parametric vs. non-parametric methods for estimating option implied risk-neutral densities: the case of the exchange rate Mexican peso – US dollar. [PDF]

This research paper presents statistical comparisons between two methods that are commonly used to estimate option implied Risk-Neutral Densities (RND). These are: 1) mixture of lognormals (MXL); and, 2) volatility function technique (VFT). The former is
Israel Felipe Mora Cuevas, Guillermo Benavides Perales   +1 more
core  

Synthesis of phase-locked counter-phase modulated pumps for SBS-suppressed fiber parametric amplifiers [PDF]

, 2010
We propose and experimentally demonstrate a new all-optical technique for the generation of two optical pumps with oppositely varying carrier phases for mitigating SBS in parametric amplifiers without phase-dither transfer from pumps to ...
J. Kakande, D. J. Richardson, Slavík, R., Parmigiani, F., Petropoulos, P., F. Parmigiani, Richardson, D.J., P. Petropoulos, R. Slavík, Kakande, J.   +9 more
core   +1 more source