Results 91 to 100 of about 10,633,056 (308)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Improving Parametric Mortgage Prepayment Models with Non-parametric Kernel Regression [PDF]
Developing a good prepayment model is a central task in the valuation of mortgages and mortgage-backed securities but conventional parametric models often have bad out-of-sample predictive ability.
Michael Marschoun +2 more
core
EnergiesLoop shaping the controller for high-order systems, especially in the presence of flexible transmission components such as elastic shafts, gearboxes, and belts commonly found in servo systems, poses significant challenges.
Pengcheng Lan, Ming Yang, Chaoyi Shang
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Hypothesis testing for two population means: parametric or non-parametric test? [PDF]
, 2019 The parametric Welch t-test and the non-parametric Wilcoxon–Mann–Whitney, empirical and exponential empirical likelihood tests are commonly used for hypothesis testing of two population means.
Alenazi, Abdulaziz +3 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
[19] J. D. Gibson and M. L. Melsa, Introduction to Non-Parametric Detection
, 2008 [16] H. V. Poor and M. Tanda, “Multiuser detection in impulsive channels,” Ann. Telecommun., vol. 54, pp. 392–400, Jul./Aug. 1999. [17] P. J. Huber, Robust Statistics. New York: Wiley, 1981. [18] B. Seyfe and A. R.
New York +7 more
core
The VARK Model Investigated at the Students from PPPE
Journal of Educational Studies, 2019 Learning style can often be the „shadow witness” of students' academic performance. Understanding and knowing this aspect may facilitate the process of academic transformation, and in some cases may suggest better methods of teaching and reporting to ...
Mihai Covaci
doaj
A Comparative Genomics Approach to the Identification of QTL Candidate Genes
Revstat Statistical Journal, 2011 Despite rapid advances in sequencing technology, many commercially relevant species remain unsequenced, and many that are sequenced have very poorly annotated genomes.
Howsun Jow +2 more
doaj +1 more source
Non-parametric manifold learning
Electronic Journal of StatisticsWe introduce an estimator for distances in a compact Riemannian manifold based on graph Laplacian estimates of the Laplace-Beltrami operator. We upper bound the error in the estimate of manifold distances, or more precisely an estimate of a spectrally truncated variant of manifold distance of interest in non-commutative geometry (cf.
openaire +2 more sources