Results 91 to 100 of about 985,928 (292)
Non-parametric manifold learning
Electronic Journal of StatisticsWe introduce an estimator for distances in a compact Riemannian manifold based on graph Laplacian estimates of the Laplace-Beltrami operator. We upper bound the error in the estimate of manifold distances, or more precisely an estimate of a spectrally truncated variant of manifold distance of interest in non-commutative geometry (cf.
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
EnergiesLoop shaping the controller for high-order systems, especially in the presence of flexible transmission components such as elastic shafts, gearboxes, and belts commonly found in servo systems, poses significant challenges.
Pengcheng Lan, Ming Yang, Chaoyi Shang
doaj +1 more source
Estimation of indirect reference intervals for serum thyrotropin using hospital records
Asian Journal of Medical Sciences, 2017 Background: Reference intervals of any biochemical analyte serve as an invaluable tool in clinical decision making. The IFCC (International Federation of Clinical Chemistry) guidelines for determining these values are not feasible in some hospital ...
Kushal Bhattarai
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The VARK Model Investigated at the Students from PPPE
Journal of Educational Studies, 2019 Learning style can often be the „shadow witness” of students' academic performance. Understanding and knowing this aspect may facilitate the process of academic transformation, and in some cases may suggest better methods of teaching and reporting to ...
Mihai Covaci
doaj
Non Parametric Models with Instrumental Variables [PDF]
This paper gives a survey of econometric models characterized by a relation between observable and unobservable random elements where these unobservable terms are assumed to be independent of another set of observable variables called instrumental ...
Florens, Jean-Pierre
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A Comparative Genomics Approach to the Identification of QTL Candidate Genes
Revstat Statistical Journal, 2011 Despite rapid advances in sequencing technology, many commercially relevant species remain unsequenced, and many that are sequenced have very poorly annotated genomes.
Howsun Jow +2 more
doaj +1 more source