Results 141 to 150 of about 16,266,310 (309)

Mass models of galaxy clusters from a non-parametric weak-lensing reconstruction

open access: yesThe Open Journal of Astrophysics
We study the CLASH sample of galaxy clusters using a new deprojection method for weak gravitational lensing observations. This method is non-parametric, allowing us to infer mass profiles, or equivalently circular velocities, without having to assume a ...
Tobias Mistele   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Environmental Efficiency Measurement with Translog Distance Functions: A Parametric Approach [PDF]

open access: yes
We use a flexible parametric hyperbolic distance function to estimate environmental efficiency when some outputs are undesirable. Cuesta and Zofio (J. Prod.
Zofío, José Luis   +2 more
core  

Multivariate Interval-Censored Survival Data: Parametric, Semi-parametric and Non-parametric Models

open access: yes, 2014
Interval censoring means that an event time is only known to lie in an interval (L,R], with L the last examination time before the event, and R the first after.
Philip Hougaard, Hougaard, Philip
core   +1 more source

Determinants of Iranian childless divorced women’s first marriage survival: a cross-sectional analysis

open access: yesSocial Determinants of Health
Background: Identifying the underlying factors contributing to the marriage survivals of childless divorced women can help increase possibility of childbearing and consequently raise of fertility rates. The aim of the present study is to investigate the
Arezoo Bagheri, Mahsa Saadati
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Efficient Estimation of Copula-based Semiparametric Markov Models [PDF]

open access: yes
This paper considers efficient estimation of copula-based semiparametric strictly stationary Markov models. These models are characterized by nonparametric invariant (one-dimensional marginal) distributions and parametric bivariate copula functions ...
Yanping Yi, Xiaohong Chen, Wei Biao Wu
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Quantile Non‑parametric Additive Models

open access: yesActa Universitatis Lodziensis. Folia Oeconomica, 2019
Quantile regression allows us to assess different possible impacts of covariates on different quantiles of a response variable. Additive models for quantile functions provide an attractive framework for non‑parametric regression applications focused on functions of the response instead of its central tendency. Total variation smoothing penalties can be
openaire   +4 more sources

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