Results 111 to 120 of about 16,266,310 (309)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
ROBUSTNESS OF NON-PARAMETRIC MEASUREMENT OF EFFICIENCY AND RISK AVERSION [PDF]
This paper examines the performance of a risk-adjusted non-parametric approach to measuring efficiency and risk aversion. Prior work is extended to the case where agent behavior is motivated by expected utility maximization. Results indicate the approach
Settlage, Daniel M., Preckel, Paul V.
core
Hospital performance evaluation models: A scoping review
Journal of Education and Health PromotionEvaluating the performance of hospitals, the largest budget consumers of the health system, is challenging. This scoping review aimed to identify and classify hospital performance evaluation models and their dimensions.
Shirin Alsadat Hadian +4 more
doaj +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Identification of Lagged Duration Dependence in Multiple Spells Competing Risks Models [PDF]
We show non-parametric identification of lagged duration dependence in mixed proportional hazard models for duration data, in the presence of competing risks and consecutive spells.
Guillaume HORNY, Matteo PICCHIO
core
Parametric and Multiobjective Optimization with Applications in Finance [PDF]
, 2010 In this thesis parametric analysis for conic quadratic optimization problems is studied. In parametric analysis, which is often referred to as parametric optimization or parametric programming, a perturbation parameter is introduced into the ...
Romanko, Oleksandr
core
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Adaptive weighted non-parametric background model for efficient video coding [PDF]
, 2017 Dynamic background frame based video coding using mixture of Gaussian (MoG) based background modelling has achieved better rate distortion performance compared to the H.264 standard.
Paul, Manoranjan +3 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source