A parametric additive hazard model for time-to-event analysis
BMC Medical Research MethodologyBackground In recent years, the use of non- and semi-parametric models which estimate hazard ratios for analysing time-to-event outcomes is continuously criticized in terms of interpretation, technical implementation, and flexibility.
Dina Voeltz +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Bayesian Semi- and Non-parametric Models for Longitudinal Data with Multiple Membership Effects in R. [PDF]
J Stat Softw, 2014 Savitsky TD, Paddock SM.
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Mass models of galaxy clusters from a non-parametric weak-lensing reconstruction
The Open Journal of AstrophysicsWe study the CLASH sample of galaxy clusters using a new deprojection method for weak gravitational lensing observations. This method is non-parametric, allowing us to infer mass profiles, or equivalently circular velocities, without having to assume a ...
Tobias Mistele +4 more
doaj +1 more source
Insights on synaptic paired-pulse response using parametric and non-parametric models. [PDF]
Annu Int Conf IEEE Eng Med Biol Soc, 2013 Bouteiller JM +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Novel non-parametric models to estimate evolutionary rates and divergence times from heterochronous sequence data. [PDF]
BMC Evol Biol, 2014 Fourment M, Holmes EC.
europepmc +1 more source
Quantile Non‑parametric Additive Models
Acta Universitatis Lodziensis. Folia Oeconomica, 2019 Quantile regression allows us to assess different possible impacts of covariates on different quantiles of a response variable. Additive models for quantile functions provide an attractive framework for non‑parametric regression applications focused on functions of the response instead of its central tendency. Total variation smoothing penalties can be
openaire +4 more sources