Results 121 to 130 of about 17,207,506 (302)

Identification of Lagged Duration Dependence in Multiple Spells Competing Risks Models [PDF]

We show non-parametric identification of lagged duration dependence in mixed proportional hazard models for duration data, in the presence of competing risks and consecutive spells.
Guillaume HORNY, Matteo PICCHIO
core  

Non-parametric estimation of forecast distributions in non-linear, non-gaussian state space models

, 2017
Non-Gaussian time series variables are prevalent in the economic and finance spheres, with state space models often employed to analyze such variables and, ultimately, to produce forecasts.
Ng, Jason Wei Jian (3718801)
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Unifying Framework for Decomposition Models of Parametric and Non-parametric Image Registration [PDF]

, 2017
Image registration aims to find spatial transformations such that the so-called given template image becomes similar in some sense to the reference image.
Ibrahim, Mazlinda, Mazlinda Ibrahim, Ke Chen, Chen, Ke   +3 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Hospital performance evaluation models: A scoping review

Journal of Education and Health Promotion
Evaluating the performance of hospitals, the largest budget consumers of the health system, is challenging. This scoping review aimed to identify and classify hospital performance evaluation models and their dimensions.
Shirin Alsadat Hadian, Reza Rezayatmand, Saeedeh Ketabi, Nasrin Shaarbafchizadeh, Ahmad Reza Pourghaderi   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Non-PH parametric survival modelling

, 2018
Non-PH parametric survival modelling is developed within the frame- work of the multiple logistic function. The family considered comprises three basic models: (a) a PH model, (b) an accelerated life model and (c) a model which is non-proportional ...
Burke, Kevin, Yasin Al-tawarah (12583627), MacKenzie, Gilbert, Al-tawarah, Yasin, Milisa Blagojevic (12583630), Gilbert Mackenzie (12348862), Blagojevic, Milisa, Kevin Burke (12352042)   +7 more
core   +1 more source

Lagged Duration Dependence in Mixed Proportional Hazard Models [PDF]

We study the non-parametric identification of a mixed proportional hazard model with lagged duration dependence when data provide multiple outcomes per individual or stratum.
Matteo PICCHIO
core