Results 151 to 160 of about 921,406 (312)

Lagged Duration Dependence in Mixed Proportional Hazard Models [PDF]

open access: yes
We study the non-parametric identification of a mixed proportional hazard model with lagged duration dependence when data provide multiple outcomes per individual or stratum.
Matteo PICCHIO
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Non-PH parametric survival modelling

open access: yes, 2018
Non-PH parametric survival modelling is developed within the frame- work of the multiple logistic function. The family considered comprises three basic models: (a) a PH model, (b) an accelerated life model and (c) a model which is non-proportional ...
Yasin Al-tawarah (12583627)   +3 more
core   +1 more source

Insights on synaptic paired-pulse response using parametric and non-parametric models. [PDF]

open access: yesAnnu Int Conf IEEE Eng Med Biol Soc, 2013
Bouteiller JM   +5 more
europepmc   +1 more source

Models and Methods for Automated Background Density Estimation in Hyperspectral Anomaly Detection

open access: yes, 2012
Detecting targets with unknown spectral signatures in hyperspectral imagery has been proven to be a topic of great interest in several applications. Because no knowledge about the targets of interest is assumed, this task is performed by searching the ...
VERACINI, TIZIANA
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Semiparametric Estimation in Multivariate Nonstationary Time Series Models [PDF]

open access: yes
A system of multivariate semiparametric nonlinear time series models is studied with possible dependence structures and nonstationarities in the parametric and nonparametric components.
Peter C.B. Phillips, Jiti Gao
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

A Non-Parametric Microsimulation Approach to Assess Changes in Inequality and Poverty [PDF]

open access: yes
This paper presents a non-parametric microsimulation methodology for assessing the determinants of changes in income inequality and poverty. One great advantage of this method over alternatives is that it is not very demanding in terms of modelling ...
Rob Vos, Marco V. Sánchez
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

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