Results 151 to 160 of about 17,207,506 (302)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Mass models of galaxy clusters from a non-parametric weak-lensing reconstruction
The Open Journal of AstrophysicsWe study the CLASH sample of galaxy clusters using a new deprojection method for weak gravitational lensing observations. This method is non-parametric, allowing us to infer mass profiles, or equivalently circular velocities, without having to assume a ...
Tobias Mistele +4 more
doaj +1 more source
A Non-Parametric Microsimulation Approach to Assess Changes in Inequality and Poverty [PDF]
This paper presents a non-parametric microsimulation methodology for assessing the determinants of changes in income inequality and poverty. One great advantage of this method over alternatives is that it is not very demanding in terms of modelling ...
Rob Vos, Marco V. Sánchez
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Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Social Determinants of HealthBackground: Identifying the underlying factors contributing to the marriage survivals of childless divorced women can help increase possibility of childbearing and consequently raise of fertility rates. The aim of the present study is to investigate the
Arezoo Bagheri, Mahsa Saadati
doaj +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Journal of King Saud University: Computer and Information SciencesThe demand for Computer-Aided Design (CAD) in industrial product development continues to grow, motivating a shift from traditional graphical interfaces toward automated parametric modeling workflows that support rapid iteration and interactive ...
Yuhao Sun +4 more
doaj +1 more source
Journal of Marine Science and EngineeringHydrodynamic models underpin Autonomous Underwater Vehicle (AUV) design, motion control, and performance evaluation. Existing methods face two critical bottlenecks: (1) conventional explicit CFD requires predefined trajectories, which fails to capture ...
Yingjie Guan +5 more
doaj +1 more source
The Use of Parametric and Non Parametric Frontier Methods to Measure the Productive Efficiency in the Industrial Sector. A Comparative Study [PDF]
Parametric frontier models and non-parametric methods have monopolised the recent literature on productive efficiency measurement. Empirical applications have usually dealt with either one or the other group of techniques.
Luis R. Murillo-Zamorano +1 more
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